Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.070 | Biomarker | disease | BEFREE | We investigated the active components against Parkinson's disease from <i>H. japonicus</i> fraction (HJF) using high performance liquid chromatography (HPLC) coupled with quadruple-time-of-flight mass spectroscopy (qTOF-MS) and NMR. | 30979037 | 2019 | ||||
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0.070 | Biomarker | disease | BEFREE | Here, we amplified α-synuclein aggregates from PD and MSA brain extracts and analyzed the conformational properties using fluorescent probes, NMR spectroscopy and electron paramagnetic resonance. | 31797870 | 2019 | ||||
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0.070 | Biomarker | disease | BEFREE | The simplicity and effectiveness of the classification methodology proposed support the use of NMR spectroscopy, in combination with chemometrics, as a viable alternative diagnostic tool to conventional PD clinical diagnosis. | 30564825 | 2019 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | The phospholipid content of purified myelin was determined by <sup>31</sup>P NMR in two mouse lines modeling PD, PrP-A53T α-Syn and Thy-1 wt-α-Syn. | 28482862 | 2017 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Our NMR data demonstrate conclusively that the differences observed in the conformational transitions triggered by Cu(I) binding to AcαS and AcβS find a correlation at the level of their backbone dynamic properties; added to the potential biological implications of these findings, this fact opens new avenues of investigations into the bioinorganic chemistry of PD. | 28820253 | 2017 | ||||
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0.070 | GeneticVariation | disease | BEFREE | Here we have used solution state NMR and circular dichroism spectroscopies to evaluate the extent of structural perturbations associated with five different Parkinson's disease linked DJ-1mutations: L166P, E64D, M26I, A104T, and D149A. | 18436956 | 2008 | ||||
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0.070 | Biomarker | disease | BEFREE | Based on NMR results, the plausible molecular mechanism of overlapping pathocascade of AD and PD in DLB due to interactions between alpha-Syn and Abeta is described. | 16947080 | 2006 |