Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.360 | Biomarker | disease | BEFREE | These findings collectively support inhibiting ASK1 as a disease modifying therapeutic strategy for Parkinson disease and related α-synucleinopathies. | 31734439 | 2020 | ||||
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0.360 | Biomarker | disease | BEFREE | These results clearly indicate that LRRK2 acts as an upstream kinase in the ASK1 pathway and plays an important role in the pathogenesis of PD. | 28888991 | 2017 | ||||
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0.360 | AlteredExpression | disease | BEFREE | In addition to its role as an antioxidant enzyme, PRX2 exhibited anti-apoptotic effects in DA neurons via suppression of apoptosis signal-regulating kinase (ASK1)-dependent activation of the c-Jun N-terminal kinase/c-Jun and p38 pro-death pathways, which are also activated in DA neurons of postmortem PD brains. | 21209210 | 2011 | ||||
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0.360 | Biomarker | disease | BEFREE | In other contexts, both the NFκB (nuclear factor κB) pathway and the ASK1 (apoptosis signaling kinase 1) pathway have been shown to be regulated by both Grx1 and Trx1, and both pathways have been implicated in cell death signaling in model systems of PD. | 21815648 | 2011 | ||||
|
0.360 | Biomarker | disease | CTD_human | In other contexts, both the NFκB (nuclear factor κB) pathway and the ASK1 (apoptosis signaling kinase 1) pathway have been shown to be regulated by both Grx1 and Trx1, and both pathways have been implicated in cell death signaling in model systems of PD. | 21815648 | 2011 | ||||
|
0.360 | GeneticVariation | disease | BEFREE | Consequently, the peripheral cysteine mutants retained cytoprotective activity, whereas the PD-associated mutant [M26I]DJ-1 failed to suppress ASK1 activity and nuclear export of the death domain-associated protein Daxx and did not promote cytoprotection. | 19293155 | 2009 | ||||
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0.360 | AlteredExpression | disease | BEFREE | This study clearly shows the route from ROS generation by 6-OHDA to initiation of p38/JNK signalling via activation of ASK1 in the studied PD model. | 16515547 | 2006 | ||||
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0.360 | AlteredExpression | disease | LHGDN | This study clearly shows the route from ROS generation by 6-OHDA to initiation of p38/JNK signalling via activation of ASK1 in the studied PD model. | 16515547 | 2006 |