PPX inhibited MPP<sup>+</sup>-induced neurotoxicity in SK-N-SH and CHP 212 cells by decreasing miR-494-3p and increasing BDNF, indicating the potential therapeutic effect of PPX on Parkinson's disease.
In conclusion, miR-494-3p inhibition exerted a neuroprotective role in MPP<sup>+</sup>-induced PD by targeting SIRT3, providing a possible therapeutic strategy for PD patients.