Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 GeneticVariation disease BEFREE We aimed to examine whether non-manifesting carriers of LRRK2 and GBA mutations have prodromal features of Parkinson's disease that correlate with reduced DAT binding. 31678032 2020
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE Higher UA levels were correlated with higher dopamine transporter uptake in the putamen in female patients with early PD. 31446637 2020
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE Furthermore, cognition-related temporal atrophy might be associated with dopaminergic deficit reflected by DAT scan but independent of CSF proteins in patients with PD who convert to PD-MCI. 31278861 2020
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 AlteredExpression disease BEFREE IRBD patients present with an intermediate state in striatal DAT distribution and PDRP activity between PD and normal controls. 30741074 2020
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 GeneticVariation disease BEFREE We analyzed longitudinal data of the specific binding ratio (SBR), a measure of striatal radiotracer uptake, in DAT SPECT from 7 patients with MSA-C, 5 patients with MSA-P, and 18 patients with PD. 31707374 2020
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE This review addresses the possibilities and limitations of DAT-SPECT in PD and, focusing specifically on regulatory changes of DAT in surviving DA neurons, we investigate its role in diagnosis and its prognostic value for motor complications as disease progresses. 31405186 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE No link between striatal dopaminergic axons and dopamine transporter imaging in Parkinson's disease. 31234224 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE Additionally, all participants underwent a battery of clinical assessments to determine motor and non-motor symptoms and cognitive status, and [<sup>123</sup>I]FP-CIT single-photon emission CT (SPECT) to assess striatal dopamine transporter binding and MRI for volumetric analyses to assess whether pathology is associated with measures of Parkinson's disease burden. 31229470 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE DAT serves as a site of action for a variety of addictive and therapeutic reuptake inhibitors, and transport dysfunction is associated with transmitter imbalances in disorders such as schizophrenia, attention deficit hyperactive disorder, bipolar disorder, and Parkinson disease. 30179648 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 AlteredExpression disease BEFREE In a macaque model of PD, also based on delivery of AAV1/2-hourA53T-aSyn to the SN, trehalose (2.67 g/kg per day, by mouth), administered for 142 days, produced higher striatal dopamine (by 39%) and dopamine transporter levels (by 50%), compared with macaques receiving vehicle. 30918068 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 GeneticVariation disease BEFREE However, the combination of the two genotypes 10R/10R (rs28363170) and A carrier (rs393795) of the DAT gene reduces the risk of LID occurrence during long-term therapy with l-DOPA with respect to the PD subjects who did not carry these alleles (OR = 0.31; 95% CI, 0.09-0.88). 30316985 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE To determine whether a multiparametric scoring system (MSS) could improve accuracy compared to each parameter of DAT-SPECT and NmMRI in differentiating PD from NDPS. 29804474 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE We investigated the association of striatal dopamine transporter (DAT) loss with cognitive function and cerebral cortical metabolism in PD. 31584466 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 AlteredExpression disease BEFREE In patients with PD, serum IGF-1 levels were negatively correlated with age and modified Rankin scale (mRS) scores and positively correlated with the striatal dopamine transporter-specific binding ratio and the frontal assessment battery score. 30903695 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 GeneticVariation disease BEFREE The aim of this study was to evaluate a possible relationship between DRD2/ANKK1 (rs1800497) and SLC6A3/DAT1 (rs28363170) gene polymorphisms with the response to levodopa (L-DOPA)-therapy in patients with Parkinson's disease (PD). 30353564 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 AlteredExpression disease BEFREE The objective of this study is to identify the dopamine transporter activity of the corpus striatum and thalamus according to myocardial <sup>123</sup>I-MIBG uptake in PD. 30796009 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE Impairments in gait kinematics and postural control may not correlate with dopamine transporter depletion in individuals with mild to moderate Parkinson's disease. 30589477 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE 6-OHDA is a neurotoxin widely used in PD animal models due to its high affinity by dopamine transporter, its rapid non-enzymatic auto-oxidation which generates reactive oxygen species (ROS), oxidative stress, and for induced mitochondrial dysfunction. 30417317 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE The laterality of the specific binding ratio (SBR) for dopamine transporter single-photon emission computed tomography may be useful for estimation of reduced dopamine transporter density in striatum of patients with Parkinson's disease. 31568269 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE We hypothesised that striatal dopamine transporter (DAT) density at the time of diagnosis might play an important role in weight regulation in patients with PD. 31102003 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE "Depressed" caudate and ventral striatum dopamine transporter availability in de novo Depressed Parkinson's disease. 31377233 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE <b>Conclusion:</b> Striatal presynaptic DAT function is clearly lower in PSP patients than in PD and MSA-P patients and is clearly lower in MSA-P patients than in MSA-C patients. 30979821 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE Striatal DAT and extrastriatal SERT binding in early-stage Parkinson's disease and dementia with Lewy bodies, compared with healthy controls: An <sup>123</sup>I-FP-CIT SPECT study. 30884365 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE Basal ganglia DAT uptake was similar between MCI-P and PD-MOT. 30611093 2019
Entrez Id: 6531
Gene Symbol: SLC6A3
SLC6A3
0.400 Biomarker disease BEFREE We report that the relationship of dopamine transporter availability with global cognition in Parkinson's disease is mediated by physical activity. 30722964 2019