Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 718
Gene Symbol: C3
C3
0.320 Biomarker disease BEFREE The gold standard for the diagnosis of pemphigus vulgaris is the detection of autoantibodies or complement component 3 by direct immunofluorescence microscopy of a perilesional biopsy. 31819769 2019
Entrez Id: 718
Gene Symbol: C3
C3
0.320 Biomarker disease BEFREE This study supports the hypothesis that complement C3 is important in PV acantholysis and that complement activation is increased by IL-1alpha and TNF-alpha. 10082594 1999
Entrez Id: 718
Gene Symbol: C3
C3
0.320 Biomarker disease CTD_human Penicillamine-induced pemphigus foliaceus. 74171 1977
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE The diagnosis of neonatal pemphigus was made after the neonate and mother were found to have elevated desmoglein 3 (Dsg3) antibodies in conjunction with histopathologic features of pemphigus vulgaris. 31774569 2020
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE The BIOCHIP was found to have a sensitivity of 60.9% and specificity of 73.6% for Dsg3 in PV. 31260565 2020
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 GeneticVariation disease BEFREE Among the large number of studied SNPs, it was found that several SNPs in different genes might control the susceptibility of PV, including TNFA (rs361525, rs1800629, rs1800629), IL10 (rs1800871, rs1800896, rs1800871, and rs1800872), IL6 (rs1800795), CTLA4 (rs231775), ICOS (rs10932029), CD86 (rs1129055), DSG3 (rs8085532, rs3911655, rs3848485, rs3794925, rs1466379), ST18 (rs2304365, rs17315309) and TAP2 (rs7454108), probably in a population-specific manner. 31342641 2020
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE Desmoglein 3, the target antigen of pemphigus vulgaris, an IgG-mediated autoimmune blistering disease, was used in a HaloTag protein barcode assay to detect the anti-DSG3 antibody. 31752022 2020
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE The mucosal-dominant subtype of PV (mdPV) is caused by PV-IgG autoantibodies against the cadherin-type adhesion molecule Dsg3. p38 mitogen-activated protein kinase (p38MAPK) signalling has been characterized as an important pathway downstream of PV-IgG binding and its inhibition is protective in ex vivo human skin. 31218663 2020
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE Sera from patients with PV contained significantly greater levels of anti-Dsg3 autoantibodies than walnut-specific antibodies, suggesting that the autoreactive B-cell response in patients with PV might be initially triggered by walnut antigens but is subsequently driven by Dsg3. 31071340 2019
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE Dsg3- but not Dsg2-deficient cells were protected against PV-IgG-induced loss of cell adhesion. 31178865 2019
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE Pemphigus vulgaris is a rare chronic blistering skin disease resulting from IgG autoantibodies directed against transmembrane desmosomal glycoprotein desmoglein 3 and is the most common form of pemphigus. 31077459 2019
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE Thus, monitoring of Dsg3-specific B cells in PV is of particular interest to further characterize the immunopathogenesis of PV. 31258541 2019
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE Here, the inhibitory antibody against Ecad but not a Dsg3-specific PV antibody interfered with stimulated lipid production. 31121132 2019
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE Autoantibodies against desmoglein (Dsg) 1 and Dsg3 primarily cause blister formation in the autoimmune disease pemphigus vulgaris (PV). 31024527 2019
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE We used three PV-IgG fractions from different patients containing high or low levels of anti-Dsg1 and anti-Dsg3 antibodies, and the presence or not of anti-desmocollin (Dsc) antibodies, using a passive transfer mouse model of PV. 31370093 2019
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE Collectively, our findings suggest a novel role for Dsg3 as an anti-stress protein, via suppression of p53 function, and this pathway is disrupted in PV. 31582719 2019
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE Pemphigus vulgaris (PV) is an autoimmune disease characterized by blistering sores on skin and mucosal membranes, caused by autoantibodies primarily targeting the cellular adhesion protein, desmoglein-3 (Dsg3). 31340153 2019
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE Immunoadsorption of Desmoglein-3-Specific IgG Abolishes the Blister-Inducing Capacity of Pemphigus Vulgaris IgG in Neonatal Mice. 30233569 2018
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE Identified almost 30 years ago, desmoglein-3 (Dsg3), a Ca<sup>2+</sup>-dependent cell adhesion molecule belonging to the cadherin family, has been considered the "primary" autoantigen in PV. 29915578 2018
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE Antibodies against desmoglein 3 (Dsg3) map to a broader array of epitopes than in pemphigus vulgaris and there is a higher prevalence of complement binding anti-Dsg3 IgG autoantibodies in PAMS. 30103046 2018
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE Desmoglein 3 (DSG3) is highly expressed in lung squamous cell carcinoma, while it is well-known that anti-DSG3 antibodies cause pemphigus vulgaris, an autoimmune disease. 30239818 2018
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 GeneticVariation disease BEFREE In the autoimmune disease pemphigus vulgaris (PV), desmoglein 3 (DSG3) and DSG1 autoantibodies are predominantly of the IgG4 subclass and less frequently of IgG1 and IgA subclasses, prompting us to investigate whether anti-DSG IgG4 B cells share lineages with IgG1, IgA1, and IgA2. 30157430 2018
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 AlteredExpression disease BEFREE The data showed that miR-338-3p expression was significantly upregulated in PV and the upregulation of miR-338-3p associated with disease severity and a high anti-Dsg3 antibody titer. 29749496 2018
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE All PV-IgG fractions and AK23 compromised Dsg3 but not Dsg1 binding and enhanced Src activity. 28620161 2017
Entrez Id: 1830
Gene Symbol: DSG3
DSG3
0.300 Biomarker disease BEFREE To define cut-off values for Dsg1, Dsg3, and BP180, we evaluated 47 serum samples from patients with pemphigus foliaceus (PF), 59 from those with pemphigus vulgaris (PV), 52 from those with bullous pemphigoid (BP), and 995 from healthy individuals. 28012821 2017