Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease CTD_human It was found that MMP-9 in oral fluid could be considered as a marker of chronic generalized periodontitis irrespective of the presence or absence of metal dental restorations. 22808498 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 GeneticVariation disease BEFREE A literature search using PubMed and Embase provided the data to conduct a meta-analysis on the associations between the TLR2 Arg753Gln, TLR4 Asp299Gly, Thr399Ile, MMP-1 -1607 G1/G2 and MMP-9 -1562 C/T polymorphisms and periodontitis. 23653009 2013
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 AlteredExpression disease BEFREE Periodontitis and poor oral hygiene were associated with elevated serum sST2 and CRP levels. 31125449 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 AlteredExpression disease BEFREE Not all patients with periodontitis had detectable levels of CRP in the GCF. 20618548 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 GeneticVariation disease BEFREE Matrix metallopeptidase-9 (MMP-9), which is known to be able to detect the progression of periodontitis in general, was not significantly different between OVX and Sham groups. 30246792 2018
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE However, patients in the PD+RA+ group had significantly higher levels of rheumatologic parameters such as C-reactive protein (CRP), anti-cyclic citrulline peptide antibody (ACPA), erythrocyte sedimentation rate (ESR), and Disease Activity Score 28 (DAS28) than those in the PD-RA+ group. 30124222 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE The highest values of sensitivity for the diagnosis of periodontitis were obtained for IL1beta (78.7%), followed by MMP8 (72.5%), IL6 and haemoglobin (72.0% for both molecules); the lowest sensitivity value was for MMP9 (70.3%). 31560804 2020
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE The results of the meta-analysis revealed statistically significant differences in the MMP-9 levels in serum and GCF between patients with periodontitis and periodontally healthy control participants. 30348440 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.400 Biomarker disease BEFREE Clinical parameters, CRP, and interleukin-6 (IL-6) concentrations were evaluated in 55 consecutive patients suffering from periodontitis at baseline, 1, 7 and 30 days after an intensive course of periodontal treatment. 15777561 2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 Biomarker disease BEFREE RECK protein expression was negatively correlated to the expressions of MMP-2 and MMP-9 in periodontitis. 28043014 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 GeneticVariation disease BEFREE MMP-9 -1562C>T contributes to periodontitis susceptibility. 23252412 2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.400 AlteredExpression disease BEFREE The present study aimed to compare levels of matrix metalloproteinase-9 (MMP-9) and myeloperoxidase (MPO) in gingival crevicular fluid (GCF) from subjects with controlled and noncontrolled Type 2 Diabetes Mellitus (T2D), with and without stage 2 grade B periodontitis (POD2B) versus healthy (H) subjects. 31355267 2019
Entrez Id: 2357
Gene Symbol: FPR1
FPR1
0.310 Biomarker disease BEFREE To date, little is known about the relationships between FPR1 and such diseases, aside from the fact that FPR1 is related to periodontitis, which is implicated in systemic diseases such as stomach cancer. 21216225 2011
Entrez Id: 2357
Gene Symbol: FPR1
FPR1
0.310 Biomarker disease GENOMICS_ENGLAND Genetic polymorphisms and periodontal disease in populations of African descent: A review. 29105764 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 GeneticVariation disease BEFREE This meta-analysis demonstrates that the TNF-α -308 A/G polymorphism confers susceptibility to periodontitis in Brazilian, Asian and Turkish populations. 23657600 2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.300 Therapeutic disease RGD Infliximab attenuates inflammatory osteolysis in a model of periodontitis in Wistar rats. 24586097 2014
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.300 GeneticVariation disease BEFREE The proportion of IL-10+ cells in the peripheral area of the periodontitis lesions was significantly larger in subjects with the -1087 IL-10 GG genotype than in subjects with the AG or AA genotype. 18315435 2008
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.300 Biomarker disease BEFREE The highest values of sensitivity for the diagnosis of periodontitis were obtained for IL1beta (78.7%), followed by MMP8 (72.5%), IL6 and haemoglobin (72.0% for both molecules); the lowest sensitivity value was for MMP9 (70.3%). 31560804 2020
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 AlteredExpression disease BEFREE The aim of this study is to compare periodontitis prevalence between controls and patients with OSA by assessing clinical periodontal parameters and gingival crevicular fluid (GCF) levels of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and high-sensitive C-reactive protein (hs-CRP); serum hs-CRP was also sampled. 27858556 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 GeneticVariation disease BEFREE The data suggest that the TNF-alpha -308 G/A polymorphism is not associated with periodontitis in this Brazilian population. 19148387 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 AlteredExpression disease BEFREE We show herein that, ASA-BMMSCs treatment reduced inflammatory infiltration and alveolar bone loss in periodontitis rats, reflected by immunohistochemistry staining of OPG/RANK-L and Micro-CT. Levels of TNF-α and IL-17 decreased while IL-10 increased after the treatment of ASA-BMMSCs in periodontitis rats. 29195233 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.300 GeneticVariation disease BEFREE When comparing genotype/allele frequencies in periodontitis versus healthy and periodontitis versus gingivitis scenarios, the number of positive associations (2-4) and the degree of association (p and odds ratio values) were significantly increased by the new approach proposed (periodontitis versus gingivitis), suggesting the association of IL1B-3954, TNFA-308, IL10-592 and TLR4-299 with periodontitis risk. 22324464 2012
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.300 GeneticVariation disease BEFREE Genetic polymorphisms in the IL-10 gene might be useful as a marker to diagnose susceptibility to periodontitis. 17335372 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease BEFREE This study evaluated whether diabetes modulates gene expression [interleukin (IL)-1beta, IL-1ra, IL-6, IL-8, IL-10; tumor necrosis factor (TNF)-alpha; interferon (IFN)-gamma, receptor activator of NF-kappaB ligand (RANKL) and osteoprotegerin (OPG)] in sites with periodontitis. 17944678 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 GeneticVariation disease BEFREE Although the genetic background of TNFalpha could be shown to be associated with subgingival colonization with P. Intermedia, there is no evidence that it is an independent risk factor for periodontitis in multivariate models. 18363738 2008