Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.260 AlteredExpression disease BEFREE Enzyme-linked immunosorbent assay (ELISA) was used to examine GCF levels of HMGB1 and NLRP3.The periodontal parameters and GCF levels of HMGB1 and NLRP3 in periodontitis patients were significantly higher before treatment, and observably decreased after 6 months of treatment as compared with the healthy group. 31689812 2019
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.260 Biomarker disease BEFREE The secreted HMGB1 mediates various inflammatory diseases, including periodontitis; however, the underlying mechanisms of HMGB1-induced periodontal inflammation are not completely understood. 29531138 2018
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.260 Biomarker disease BEFREE The higher levels of sTREM1 and HMGB1 cytokines in GCF of periodontitis patients and the significant decrease after the introduction of the periodontal treatment underlines the importance of HMGB1 and sTREM1 in pathogenesis of periodontitis. 29338161 2017
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.260 Biomarker disease BEFREE There is a possible relationship between periodontitis and post-infarction myocardial inflammation through HMGB-1. 28966323 2017
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.260 Biomarker disease BEFREE This study aimed to investigate the presence of the periodontal pathogen Treponema denticola, apoptosis, high mobility group box 1 as a damage-associated molecular pattern, and several inflammatory markers in periodontitis and gingivitis subjects. 28686335 2017
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.260 Biomarker disease BEFREE Further research is needed for understanding the role of HMGB1 in smoking and pathogenesis of periodontitis. 28209360 2017
Entrez Id: 3146
Gene Symbol: HMGB1
HMGB1
0.260 Biomarker disease RGD In conclusion, this study demonstrates that HMGB1 may be associated with the onset and progression of periodontitis, suggesting that further studies should investigate the potential role of HMGB1 on periodontal tissue destruction. 24692854 2014