Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.290 GeneticVariation disease BEFREE Two functional polymorphisms in the matrix metalloproteinase-2 and -9 (<i>MMP-2</i> and <i>MMP-9</i>) genes may contribute to periodontitis pathogenesis. 31497543 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.290 GeneticVariation disease BEFREE To determine whether circulating levels of two matrix metalloproteinases, MMP-2 and MMP-9, are associated with loss of alveolar bone density (ABD) or height (ABH), or with progression of periodontitis (relative clinical attachment level [RCAL]), among postmenopausal women with local and systemic bone loss. 31032961 2019
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.290 Biomarker disease BEFREE This study aims to investigate the role of EMMPRIN glycosylation in regulating MMP-2 and MMP-9 during the progression of periodontitis. 29315565 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.290 Biomarker disease BEFREE Interaction between the Wnt/β-catenin signaling pathway and the EMMPRIN/MMP-2, 9 route in periodontitis. 29900539 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.290 AlteredExpression disease BEFREE RECK protein expression was negatively correlated to the expressions of MMP-2 and MMP-9 in periodontitis. 28043014 2017
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.290 Biomarker disease BEFREE In addition, human gingival fibroblasts (HGFs) were tested for production of IL-6 and MMP-2 after stimulation with hydrocortisone (HC), MIF, tumour necrosis factor-alpha (TNF-α), or Fusobacterium nucleatum, a pathogen known to elicit immune responses during periodontitis. 28776753 2017
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.290 GeneticVariation disease BEFREE Our results revealed that although studies of the association between MMP-8 -799 C/T variant and the susceptibility to periodontitis have not yielded consistent results, MMP-1 (-1607 1G/2G, -519 A/G, and -422 A/T), MMP-2 (-1575 G/A, -1306 C/T, -790 T/G, and -735 C/T), MMP-3 (-1171 5A/6A), MMP-8 (-381 A/G and +17 C/G), MMP-9 (-1562 C/T and +279 R/Q), and MMP-12 (-357 Asn/Ser), as well as MMP-13 (-77 A/G, 11A/12A) SNPs are not related to periodontitis risk.Conclusions. 27194818 2016
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.290 GeneticVariation disease BEFREE In summary, current evidence demonstrated that MMP-9-753 C/T polymorphism reduced the risk of periodontitis, MMP-3-1171 5A/6A and MMP-8-799 C/T polymorphisms increased the risk of periodontitis, and MMP-2-753 C/T was not associated with risk of periodontitis. 27095260 2016
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.290 Biomarker disease RGD MMP-2 and MMP-3 may play an important role in development of periodontitis. 16845949 2006
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.290 GeneticVariation disease BEFREE Our findings suggest that polymorphisms in the MMP-2 gene promoter do not contribute significantly to the interindividual periodontitis susceptibility and/or severity in European Caucasians, and they are not regulatory variants in this disease. 16018746 2005