|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The total amounts and concentrations of SLIT3 and RANKL were significantly higher in periodontitis than those in healthy, while the level of OPG was significantly lower (p < .05).
|
31696592 |
2020 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, LP17 also significantly downregulated the receptor activator of nuclear factor kappa-B-ligand (RANKL) to osteoprotegerin (OPG) ratio that drives osteoclastic bone resorption in periodontitis.
|
31581596 |
2019 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similarly, significantly higher levels of TWEAK (p = 0.001), RANKL(p < 0.0001), and OPG(p = 0.025) were detected in periodontitis group when compared to periodontal health group.
|
30377055 |
2019 |
|
TNFRSF11B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis showed that increased levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and acid phosphatase (ACP) were all associated with periodontitis (p < 0.05), while blood urea nitrogen (BUN) and osteoprotegerin (OPG) levels did not show statistical differences between cases and controls (p > 0.05).
|
30986096 |
2019 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ratio of receptor activator of nuclear factor-κB ligand (RANKL)/osteoprotegerin, a biomarker of periodontitis and osteolysis, was significantly decreased by ECE administration (<i>p</i> < 0.05).
|
31121899 |
2019 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aimed to analyze the expression of Notch signaling molecules (Notch2, Jagged1, and Hey1) and proinflammatory cytokines (tumor necrosis factor alpha [TNF-α], interleukin [IL]-1β, and IL-6) in human apical periodontitis lesions with different receptor activator of nuclear factor kappa B ligand (RANKL)/osteoprotegerin (OPG) ratios and determine their potential correlation.
|
30580840 |
2019 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aimed to investigate the chemical characteristics and the effects of an orabase gel with Cashew Gum Polysaccharide (CG-P) from Anacardium occidentale L. on alveolar bone loss and relative mRNA expression of TNF-α, IL-1β, RANK, RANKL, and OPG in the periodontal tissue of Wistar rats (Rattus norvegicus) subjected to ligature-induced periodontitis.
|
28964840 |
2018 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Assessment of local and systemic 25-hydroxy-vitamin D, RANKL, OPG, and TNF levels in patients with rheumatoid arthritis and periodontitis.
|
28904316 |
2017 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies in patients indicate that B cells and plasma cells, together with osteoclastogenic factors (RANKL and osteoprotegerin) and specific cytokines involved in their growth and differentiation (BAFF and APRIL) participate in the induction of the pathological bone loss in periodontitis.
|
28013554 |
2017 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, in the present study, we tested the selective sEH inhibitor, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), in a mouse model of periodontitis induced by infection with <i>Aggregatibacter actinomycetemcomitans</i> Oral treatment of wild-type mice with TPPU and sEH knockout (KO) animals showed reduced bone loss induced by <i>A. actinomycetemcomitans</i> This was associated with decreased expression of key osteoclastogenic molecules, receptor activator of nuclear factor-κB/RANK ligand/osteoprotegerin, and the chemokine monocyte chemotactic protein 1 in the gingival tissue without affecting bacterial counts.
|
28356494 |
2017 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Local recombinant OPG plasmid-mediated gene therapy suppresses osteoclastogenesis in vivo and inhibits alveolar bone height reduction caused by experimental periodontitis in rats.
|
25203865 |
2015 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vivo study showed that MT01 prevented the loss of alveolar bone in the rats with periodontitis and induced the production of proteins of OPG and Osterix in the bone tissue.
|
22489131 |
2012 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although further investigation is needed to identify the specific role of RANKL and OPG protein in periodontitis progression, our data after SRP might indicate the possible involvement of these proteins in the activation of pathways, which regulate the repair of the periodontal tissues.
|
20033478 |
2010 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This increased prevalence is unrelated to secondary Sjögren's syndrome but instead reflects shared pathogenic mechanisms, including an increased prevalence of the shared epitope HLA-DRB1-04; exacerbated T-cell responsiveness with high tissue levels of IL-17; exaggerated B-cell responses, with plasma cells being the predominant cell type found within gingival tissue affected with periodontitis and B cells being twice as numerous as T cells; RANK overexpression; and an increase in the ratio of RANK-L over osteoprotegerin with a high level of RANK-L expression on gingival B cells, most notably those capable of recognizing Porphyromonas gingivalis.
|
20646949 |
2010 |
|
TNFRSF11B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the association of polymorphism in the osteoprotegerin gene with susceptibility to chronic kidney disease and periodontitis.
|
18624938 |
2008 |
|
TNFRSF11B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The TG haplotype of T950C and G1181C polymorphisms in the OPG gene may be useful genetic markers for the prediction of periodontitis.
|
18938269 |
2008 |
|
TNFRSF11B
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The TG haplotype of T950C and G1181C polymorphisms in the OPG gene may be useful genetic markers for the prediction of periodontitis.
|
18938269 |
2008 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Receptor Activator of NF-kappaB Ligand (RANKL) stimulates bone resorption, whereas osteoprotegerin (OPG) blocks its action, and this bi-molecular system is implicated in periodontitis.
|
17448630 |
2007 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Diabetes lowered IL-1beta, IL-8, IL-10, TNF-alpha, RANKL, and OPG mRNA levels in sites with comparable type of periodontitis (P < 0.001).
|
17944678 |
2007 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The RANKL/OPG expression ratio was significantly higher in the periodontitis group compared to the healthy control group (P = 0.001).
|
17539720 |
2007 |
|
TNFRSF11B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
OPG and RANKL mRNA were expressed in 80% (16/20) and 25% (5/20) of periodontitis lesions, respectively.
|
12390325 |
2002 |
|
TNFRSF11B
|
0.100 |
Biomarker
|
disease |
BEFREE |
PDL cells might regulate osteoclastogenesis by opposing mechanisms--stimulation of resorptive activity by RANKL and inhibition by OPG--thus affecting processes such as periodontitis and orthodontic tooth movement.
|
11379890 |
2001 |