Similar multi-level results have been reported for genetic and epigenetic variation in the OXTR gene, especially in social anxiety disorder (SAD), and for CRHR1 gene variation in women with panic disorder.
The present pilot data point to a strong association of less secure attachment and social anxiety as well as to a gene-environment interaction effect of OXTRrs53576 genotype and attachment style on social anxiety possibly constituting a targetable combined risk marker of social anxiety disorder.