Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.200 GeneticVariation disease BEFREE Pituitary adenomas (PAs) may rarely occur in well-defined hereditary conditions, like multiple endocrine neoplasia type 1 (MEN1) syndrome and familial isolated pituitary adenoma (FIPA) associated with germline mutations in MEN1 and AIP, respectively. 30630164 2019
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.200 GeneticVariation disease BEFREE PPARα was expressed in a majority of PA. PPARα immunostaining was observed in 93.7% PRL-PA vs. 60.6% NFPA (p=0.016), the opposite being found for AIP (83.3% in NFPA vs. 43.7% in PRL-PA, p=0.003). 30021235 2018
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.200 GeneticVariation disease BEFREE The AIP c.911G>A: rs104894190" genes_norm="9049">p.Arg304Gln (rs104894190) variant was detected in only two patients with functional PA: one with somatotropinoma [in 1/55 (1.8%)] and one with prolactinoma [in 1/25 (4%)]. 30461320 2018
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.200 Biomarker disease BEFREE Aryl Hydrocarbon Receptor-Interacting Protein (AIP) N-Terminus Gene Mutations Identified in Pituitary Adenoma Patients Alter Protein Stability and Function. 28255869 2017
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.200 GeneticVariation disease BEFREE Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers. 26186299 2015
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.200 AlteredExpression disease BEFREE Similarly, in vitro octreotide induced a median twofold increase in AIP expression (range 1.2-13.9, P=0.027) in GH-PA. 23940012 2013
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.200 GeneticVariation disease BEFREE The aryl hydrocarbon receptor interacting protein gene (AIP) is associated with pituitary adenoma (PA). 24050928 2013
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.200 GeneticVariation disease BEFREE Thus, germline AIP or MEN1 gene mutations are frequent among pediatric patients with GH- or PRL-secreting PA but are significantly rarer in pediatric CD; PRKAR1A mutations are not present in PA outside of Carney complex. 20507346 2010
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.200 GeneticVariation disease BEFREE Mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene have been described in about 15% of kindreds with familial isolated pituitary adenomas and in a minority of early onset sporadic pituitary adenomas (PA). 20354355 2010
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.200 GeneticVariation disease BEFREE Germline mutations of the aryl hydrocarbon receptor (AHR)-interacting protein (AIP) gene confer a predisposition to pituitary adenomas (PA), usually in the setting of familial isolated PA. To provide further insights into the possible role of AIP in pituitary tumour pathogenesis, the expression of AIP and AHR was determined by real-time RT-PCR and/or immunohistochemistry (IHC) in a large series of PA (n=103), including 17 with AIP mutations (AIP(mut)). 19556287 2009
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.200 GeneticVariation disease BEFREE Pituitary adenoma predisposition (PAP) has been recently associated with germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene. 18410548 2008
Entrez Id: 9049
Gene Symbol: AIP
AIP
0.200 Biomarker disease HPO