Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.080 | Biomarker | disease | BEFREE | Compared with wild-type (WT) mice, CS-induced pulmonary inflammation was unaltered in TLR2-deficient ( Tlr2<sup>-/-</sup>) and TLR4-deficient ( Tlr4<sup>-/-</sup>) mice. | 29025711 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | Moreover, we found that PPARγ activation not only inhibited CS/LPS-induced TLR2/4 expression and <i>miR-27-3p</i>-mediated TLR2/4 signaling cascades involving the nuclear factor-κB (NF-κB), c-Jun NH<sub>2</sub>-terminal kinase (JNK)/p38, and Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathways in AMs but also ameliorated CS/LPS-induced AM activation and pulmonary inflammation. | 29572385 | 2018 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Patients carrying the TLR2 SNP rs5743708 (R753Q, GA/AA genotype, n = 12) also revealed a significantly higher susceptibility to pneumonia including IFD. | 26963509 | 2016 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The presence of the TLR2 Arg753Gln polymorphism was significantly associated with pneumonia in AML patients (odds ratio (OR): 10.78; 95% confidence interval (CI): 2.0-58.23; P=0.006). | 25427560 | 2015 | ||||
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0.080 | Biomarker | disease | BEFREE | As quantified by blinded scoring of lung pathology, P. acnes-induced granulomatous pulmonary inflammation was markedly attenuated in TLR-2(-/-) mice compared to wild-type C57BL/6 animals. | 23668840 | 2013 | ||||
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0.080 | Biomarker | disease | BEFREE | MicroRNA-21 inhibits toll-like receptor 2 agonist-induced lung inflammation in mice. | 21892915 | 2011 | ||||
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0.080 | Biomarker | disease | BEFREE | These results highlight the proinflammatory properties of PVL and identify CD14/TLR2 as an essential receptor complex for PVL-induced lung inflammation. | 21178007 | 2011 | ||||
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0.080 | Biomarker | disease | BEFREE | These data suggest that TLR2 is the single most important receptor signaling the presence of LTA within the lungs in vivo, whereas TLR4 and PAFR may influence lung inflammation induced by LTA either by sensing LTA directly or through recognition and signaling of endogenous mediators induced by the interaction between LTA and TLR2. | 18292574 | 2008 |