Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2 		0.510 Biomarker disease BEFREE However, upon induction of pneumococcal pneumonia in aged mice, delayed production of certain analytes, such as IFN-γ, MIG (CXCL9), IP-10 (CXCL10), MCP-1 (CCL2), TARC (CCL17) and MDC (CCL22) became apparent. 30463053 2018
Entrez Id: 6347
Gene Symbol: CCL2
CCL2 		0.510 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
Entrez Id: 6347
Gene Symbol: CCL2
CCL2 		0.510 Biomarker disease CTD_mouse Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
Entrez Id: 834
Gene Symbol: CASP1
CASP1 		0.310 Biomarker disease BEFREE Here, we show that the inflammasome components ASC and NLRP3 are required for resistance to pneumococcal pneumonia, whereas caspase-1 and caspase-11 are dispensable. 31278375 2019
Entrez Id: 4283
Gene Symbol: CXCL9
CXCL9 		0.310 Biomarker disease BEFREE However, upon induction of pneumococcal pneumonia in aged mice, delayed production of certain analytes, such as IFN-γ, MIG (CXCL9), IP-10 (CXCL10), MCP-1 (CCL2), TARC (CCL17) and MDC (CCL22) became apparent. 30463053 2018
Entrez Id: 3458
Gene Symbol: IFNG
IFNG 		0.310 Biomarker disease BEFREE However, upon induction of pneumococcal pneumonia in aged mice, delayed production of certain analytes, such as IFN-γ, MIG (CXCL9), IP-10 (CXCL10), MCP-1 (CCL2), TARC (CCL17) and MDC (CCL22) became apparent. 30463053 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.310 GeneticVariation disease BEFREE To address this issue, we have utilized a murine model of pneumococcal pneumonia in which the gene for the IL-17 cytokine family receptor, Il17ra, has been inactivated. 29813133 2018
Entrez Id: 6361
Gene Symbol: CCL17
CCL17 		0.310 Biomarker disease BEFREE However, upon induction of pneumococcal pneumonia in aged mice, delayed production of certain analytes, such as IFN-γ, MIG (CXCL9), IP-10 (CXCL10), MCP-1 (CCL2), TARC (CCL17) and MDC (CCL22) became apparent. 30463053 2018
Entrez Id: 4283
Gene Symbol: CXCL9
CXCL9 		0.310 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
Entrez Id: 834
Gene Symbol: CASP1
CASP1 		0.310 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.310 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
Entrez Id: 3458
Gene Symbol: IFNG
IFNG 		0.310 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.310 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
Entrez Id: 6361
Gene Symbol: CCL17
CCL17 		0.310 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.310 Biomarker disease BEFREE Interleukin-6 (IL-6) is required for the clearance of bacteria in pneumococcal pneumonia. 16005243 2005
Entrez Id: 3551
Gene Symbol: IKBKB
IKBKB 		0.300 Biomarker disease CTD_human Glucose Homeostasis following Diesel Exhaust Particulate Matter Exposure in a Lung Epithelial Cell-Specific IKK2-Deficient Mouse Model. 31095431 2019
Entrez Id: 1958
Gene Symbol: EGR1
EGR1 		0.300 Therapeutic disease CTD_human Early growth response gene 1 is essential for urban particulate matter-induced inflammation and mucus hyperproduction in airway epithelium. 29787794 2018
Entrez Id: 183
Gene Symbol: AGT
AGT 		0.300 Therapeutic disease CTD_human Angiotensin-(1-7)-mediated Mas1 receptor/NF-κB-p65 signaling is involved in a cigarette smoke-induced chronic obstructive pulmonary disease mouse model. 28960804 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.300 Therapeutic disease CTD_human Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM2.5. 28917655 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.300 Biomarker disease CTD_human Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM2.5. 28917655 2017
Entrez Id: 4615
Gene Symbol: MYD88
MYD88 		0.300 Biomarker disease CTD_human Desert dust induces TLR signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway. 26882889 2016
Entrez Id: 7099
Gene Symbol: TLR4
TLR4 		0.300 Biomarker disease CTD_human Desert dust induces TLR signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway. 26882889 2016
Entrez Id: 90865
Gene Symbol: IL33
IL33 		0.300 Biomarker disease CTD_human A20-deficient mast cells exacerbate inflammatory responses in vivo. 24453940 2014
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1 		0.300 Therapeutic disease CTD_human SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. 24633890 2014
Entrez Id: 196
Gene Symbol: AHR
AHR 		0.300 Biomarker disease CTD_human Functional deficiency of aryl hydrocarbon receptor augments oxygen toxicity-induced alveolar simplification in newborn mice. 23337360 2013