Pro-/synbiotic supplementation significantly reduced fasting blood sugar (-2.52 mg/dl, 95% confidence interval (CI): -4.10 to -0.95), insulin (-2.27 µIU/mL, 95% CI: -3.40 to -1.14), homeostasis model assessment for insulin resistance index (-0.69, 95% CI: -0.98 to -0.40), C-reactive protein (-1.69 Hedges', 95% CI: -3.00 to -0.38), and total testosterone (-0.12 ng/mL, 95% CI: -0.17 to -0.08) in women with PCOS.
Women with polycystic ovary syndrome (PCOS) have higher circulating levels of C-reactive protein, but the relationship between inflammation and endocrine function in PCOS remains poorly understood.
All the concentrations of inflammatory factors including C-reactive protein (CRP), interleukin (IL)-6, IL-18, and tumor necrosis factor (TNF)-α. were significantly higher in PCOS group than the control group (P < 0.001).
Among women with PCOS, AMH inversely related to BMI (p<0.001), and also to WC (p<0.001), fasting insulin (p<0.01), HOMA-IR (p<0.01), triglycerides (p=0.04) and CRP (p<0.001) and directly related to higher total (p=0.02), LDL (p<0.01), and HDL cholesterol (p<0.01).