Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 GeneticVariation disease BEFREE We conclude that the extent of JAK2(V617F) CD34(+) cell clonal dominance is associated with disease phenotype within the MPD and, in PV, is associated with extramedullary disease, leukocytosis, and disease duration. 18723264 2008
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 GeneticVariation disease BEFREE A JAK2 (V617F) gene dosage effect on both CD34(+) cell counts and granulocyte activation was clearly demonstrated in polycythemia vera, where abnormal patterns were mainly found in patients carrying more than 50% mutant alleles. 16373657 2006
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 GeneticVariation disease BEFREE Peripheral blood CD34(+) cells isolated from PV patients and healthy controls were grown in liquid culture to expand a population of primary erythroblasts for experiments designed to analyze cellular proliferation, apoptosis, JAK2(V617F) mutation status, cytokine-dependent protein phosphorylation and gene expression profiling using Affymetrix microarrays. 19815050 2009
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 GeneticVariation disease BEFREE Genetic or PAD-mediated PP2A reactivation induces Jak2(V617F) inactivation/downregulation and impairs clonogenic potential of Jak2(V617F) cell lines and PV but not normal CD34(+) progenitors. 23926298 2013
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 GeneticVariation disease BEFREE The present data suggests the JAK2 V617F allele burden as a key determinant of the degree of myeloproliferation and myeloid metaplasia reflected by significantly higher levels of white blood cell counts (WBC) (P = 0.03), CD34 counts (P = 0.03), lactate dehydrogenase and Polycythemia Rubra Vera gene 1 levels (P = 0.03 and P < 0.00001 respectively), as well as lower platelet counts (P = 0.02) and more cases of splenomegaly (P = 0.001) in homozygous PV patients compared to their heterozygous counterparts. 17961178 2007
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE In this study selected CD34+ peripheral blood (PB) cells from PV patients, PB healthy donors and patients with secondary polycythemia (SP) were investigated and compared concerning frequency, morphology, antigen expression, transcription of differentiation markers and proliferation as well as apoptosis rate following short-term culture. 12851693 2003
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE These two 14- and 12-gene sets could separate not only PV from normal CD34(+) specimens, but also other MPN such as essential thrombocytosis and primary myelofibrosis from their normal counterparts. 20601445 2010
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE Following cDNA subtraction using mRNAs isolated from PV and normal CD34+/CD33- bone-marrow cells, expression of the tumour suppressor H19 was found to be low or absent in the PV sample. 10640993 2000
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE Three consecutive polycythemia vera (PV) patients were analyzed before and during pegylated-interferon (rIFNalpha) treatment for the following markers: (1) granulocyte and CD34(+) cell clonality, (2) Jak2V617F expression, (3) PRV-1 mRNA overexpression, and (4) Epo-independent colony (EEC) growth. 17256145 2007
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE We evaluated the NOD/SCID engraftment of CD34(+) cells from polycythemia vera (PV) and secondary polycythemia patients (SP) and the JAK2V617F clone before and after transplantation. 20170959 2010
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE The exposure of PV CD34(+) cells to low doses of IFNα and ABT-737 in combination resulted in the reduction of the proportion of JAK2V617F(+) colonies similar to that observed with higher doses of IFNα. 20625010 2010
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE Peripheral blood (PB) CD34(+) cells from patients with polycythemia vera (PV) and primary myelofibrosis (PMF) generated in vitro significantly fewer mast cells (MCs) than normal PB CD34(+) cells. 19387466 2009
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE CD34+ HPCs were cultured in medium supplemented with serum samples of PV, ET, or MF patients, or healthy controls. 29851963 2018
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE Moreover, a marked augmentation in HR activity was found in CD34(+)-derived cells isolated from patients with polycythemia vera or primitive myelofibrosis compared with control samples. 18515659 2008
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE No mutations were found in these genes; however, unexpectedly, increased expression of the transcription factor NFI-B was detected in granulocytes and CD34(+) cells in PV with 9pLOH. 11882360 2002
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE These factors may contribute to the accumulation of chromosomal aberrations, accumulation of hematopoietic cells (especially of erythropoiesis), and prolongation of CD34+ PBSC life span observed in PV. 19004005 2009
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE No evidence for an altered mRNA expression or protein level of haematopoietic cell phosphatase in CD34+ bone marrow progenitor cells or mature peripheral blood cells in polycythaemia vera. 9414643 1997
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE Conversely, exposure of polycythemia vera CD34(+) cells to small interfering RNA against pre-miR-16-2 reduced erythroid colonies and largely prevented formation of erythropoietin-independent colonies; myeloid progenitors remained unaffected. 21527532 2011
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE Treatment of polycythemia vera (PV) and primary myelofibrosis (PMF) CD34(+) cells with low doses of RG7112 and Peg-IFNα 2a before their transplantation into immune-deficient mice decreased the degree of donor-derived chimerism as well as the JAK2V617F allele burden, indicating that these drugs can each alone or in combination deplete MPN HSCs. 24869939 2014
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 Biomarker disease BEFREE The finding of a distinct, not aberrant, CD34(+) progenitor cell population in chronic phase PV may offer perspectives in treatment of the disease. 16133363 2005
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 AlteredExpression disease BEFREE Here we demonstrated that elevation of NF-E2 expression in healthy CD34(+) cells to levels observed in PV caused Epo-independent erythroid maturation and expansion of hematopoietic stem cell (HSC) and common myeloid progenitor (CMP) cell numbers. 23341442 2013
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 AlteredExpression disease BEFREE We analyzed gene expression in CD34+ peripheral-blood cells from 19 patients with polycythemia vera, using oligonucleotide microarray technology after correcting for potential confounding by sex, since the phenotypic features of the disease differ between men and women. 25162887 2014
Entrez Id: 947
Gene Symbol: CD34
CD34
0.100 AlteredExpression disease BEFREE Treatment with low doses of Peg IFN-α 2a combined with Nutlin-3 increased phospho-p53 and p21 protein levels in PV CD34(+) cells and increased the degree of apoptosis. 22872685 2012