In samples from 151 patients with myeloproliferative neoplasms, there was a modest inverse correlation between the expression levels of <i>let-7a</i> and <i>HMGA2</i> Overexpression of <i>HMGA2</i> was detected in 29 (19.2%) of the cases, and it was more commonly seen in patients with essential thrombocythemia than in those with polycythemia vera (26.9% <i>vs</i> 12.7%, <i>P</i>=0.044).
HMGA2 mRNA expression, especially variant 1 with 3'UTR that contains MIRLET7-specific sites, rather than variant 2 lacking 3'UTR, is frequently deregulated due to decreased MIRLET7 expression in granulocytes from over 20% of PV and ET, and in either granulocytes or CD34(+) cells from 100% of PMF.