Loss of the adaptor protein cyclin-dependent kinase regulatory subunit 1 (Cks1), a cofactor of the SCF<sup>Skp2</sup> ubiquitin ligase complex and a downstream target of MYC, increases p27<sup>kip1</sup> expression during a premalignant stage.
Here, we report that Myc controls transcription of the lactate transporter SLC16A1/MCT1 and that elevated MCT1 levels are manifest in premalignant and neoplastic Eμ-Myc transgenic B cells and in human malignancies with MYC or MYCN involvement.