Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE Overexpression of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) and increasing mast cell density (MCD) in premalignant and malignant oral lesions have been documented. 27577989 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE It is now well established that COX-2 is overexpressed in many premalignant, malignant, and metastatic cancers, including hepatocellular carcinoma (HCC). 21042835 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Elevated cyclooxygenase-2 (COX-2) expression is observed in a variety of premalignant neoplastic tissues, suggesting COX-2 expression might serve as a potential indicator of subsequent tumor development. 20599447 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE Pharmacologic inhibitors of the prostaglandin-synthesizing COX-2 oncogene prevent the development of premalignant human colon adenomas. 19470469 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group CTD_human Anti-Helicobacter pylori therapy followed by celecoxib on progression of gastric precancerous lesions. 19522023 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions. 18559542 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Although COX-2 is commonly overexpressed in a variety of premalignant and malignant conditions including oral leukoplakia and squamous cell carcinoma, relatively little research has compared the effects of various COX-2 inhibitors (celecoxib, NS-398, nimesulide and meloxicam). 18202791 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE We found that celecoxib inhibited the growth of premalignant and malignant human bronchial epithelial cells with IC(50) values between 8.9 and 32.7 micromol/L, irrespective of cyclooxygenase-2 (COX-2) expression. 17018636 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions. 16733863 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE While COX-2 expression in normal breast epithelium in vivo has not been proven to be linked to an increased risk of breast cancer, its over-expression in the premalignant model in vitro does provide preliminary evidence that COX-2 inhibition may be a useful chemoprevention strategy. 15642177 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation group BEFREE Barrett's oesophageal epithelium (BE) is a premalignant condition in which cyclooxygenase-2 (COX-2) levels are increased. 15878911 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Cyclooxygenase-2 (Cox-2), an enzyme that catalyzes the synthesis of prostaglandins, is overexpressed in a variety of premalignant and malignant conditions, including urinary bladder cancer. 15240520 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE The COX-2 enzyme has been reported to be over-expressed in premalignant and malignant states, including in Barrett's esophagus and esophageal adenocarcinoma. 14641306 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE COX-2 was up-regulated from healthy to premalignant to cancerous oral mucosa. 12747975 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE For glandular lesions, 6 of 10 (60%) AC from high-risk area and 15 of 20 (75%) from low-risk area showed positive COX-2 staining, and 12 of 17 (70%) premalignant Barrett's esophagus were also positive. 12893070 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE To evaluate its utility as an intermediate biomarker in bronchial chemoprevention trials, the authors examined Cox 1 and Cox 2 expression in normal and premalignant bronchial epithelial cells and nonsmall cell lung carcinoma (NSCLC) samples using an immunohistochemical staining technique. 11920472 2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group CTD_human Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. 12151359 2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE These data collectively imply COX-2 may play an important role during premalignant hyperproliferation, as well as the later stages of invasive carcinoma and metastasis in various human epithelial cancers. 12051953 2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE We investigated the distribution and intensity of COX-2 expression in premalignant and malignant gastric lesions, and monitored the changes after H. pylori eradication. 10980112 2000
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Cyclooxygenase-2 (COX-2) is overexpressed in various types of human malignancies including squamous cell carcinomas (SCCs) of the esophagus, but little is known about COX-2 expression in premalignant esophageal squamous dysplasia. 10778945 2000