Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A 		0.120 Biomarker disease HPO
Entrez Id: 7273
Gene Symbol: TTN
TTN 		0.100 Biomarker disease HPO
Entrez Id: 2702
Gene Symbol: GJA5
GJA5 		0.100 Biomarker disease HPO
Entrez Id: 9992
Gene Symbol: KCNE2
KCNE2 		0.100 Biomarker disease HPO
Entrez Id: 8560
Gene Symbol: DEGS1
DEGS1 		0.010 Biomarker disease BEFREE % MLD stenosis in AIP group was significantly lower than that in PAC group (p < 0.0001). 29948059 2018
Entrez Id: 410
Gene Symbol: ARSA
ARSA 		0.010 Biomarker disease BEFREE % MLD stenosis in AIP group was significantly lower than that in PAC group (p < 0.0001). 29948059 2018
Entrez Id: 7514
Gene Symbol: XPO1
XPO1 		0.010 AlteredExpression disease BEFREE <i>XPO1</i> expression refines the prognostication in PAC and higher expression exists in secondary versus primary tumors, which supports the development of <i>XPO1</i> inhibitors in this so-lethal disease. 31052304 2019
Entrez Id: 10297
Gene Symbol: APC2
APC2 		0.020 Biomarker disease BEFREE APC and APC2 may therefore have comparable functions in development and cancer. 10021369 1999
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.100 Biomarker disease BEFREE APC affects the degradation of beta-catenin by its NH(2)-terminal phosphorylation on the serine/threonine residues of exon 3. 10754205 2000
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.100 AlteredExpression disease BEFREE APC truncation and increased beta-catenin levels in a human breast cancer cell line. 10874025 2000
Entrez Id: 2520
Gene Symbol: GAST
GAST 		0.010 Biomarker disease BEFREE APC(min-/+) mice overexpressing one of the alternatively processed forms of gastrin, glycine-extended gastrin, show a significant increase in polyp number. 10953028 2000
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.100 AlteredExpression disease BEFREE APC is expressed in a wide variety of tissues, interacts with the cytoskeleton, is involved in regulating levels of beta-catenin and, most recently, has been shown to bind DNA, suggesting that it may possess a nuclear role. 11099951 2000
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.100 AlteredExpression disease BEFREE APC is known to down regulate beta-catenin levels, a transducer of Wnt signaling. 11687966 2001
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.100 Biomarker disease BEFREE APC downregulates nuclear beta-catenin, which is thought to be critical for its tumour suppressor function. 11689433 2001
Entrez Id: 10763
Gene Symbol: NES
NES 		0.010 Biomarker disease BEFREE APC-(129-250) includes the nuclear export signal NES-(165-174) at the C-terminal end of the first helix. 12070164 2002
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.100 GeneticVariation disease BEFREE APC and CTNNB1 mutations in a large series of sporadic colorectal carcinomas stratified by the microsatellite instability status. 12408524 2002
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1 		0.060 PosttranslationalModification disease BEFREE APC methylation and GSTP1 methylation in the primary tumor were both correlated with nonsquamous histology (P = 0.02 and P = 0.01 likelihood ratio respectively). 12684406 2003
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.100 Biomarker disease BEFREE APC colocalized with beta-catenin in the nucleus only in one cell line (SW480). 12955080 2003
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1 		0.030 Biomarker disease BEFREE APC was hypermethylated in 15 of 34 (47%), RASSF1A in 22 of 34 (65%), and DAP-kinase in 17 of 34 (50%) tumors. 15448006 2004
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.100 Biomarker disease BEFREE APC forms a multi-protein complex involved in the WNT signalling pathway that controls the stability of beta-catenin, the central effector in this cascade. 15538750 2004
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.100 AlteredExpression disease BEFREE APC is known to regulate the levels of beta-catenin, an important mediator of cell-cell adhesion and transcriptional regulator. 15769611 2005
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.100 AlteredExpression disease BEFREE APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers. 15951972 2005
Entrez Id: 6347
Gene Symbol: CCL2
CCL2 		0.010 AlteredExpression disease BEFREE APC significantly inhibited in vitro the expression of TNFalpha and MCP-1 from LI90 stellate cells. 16497622 2006
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.100 Biomarker disease BEFREE APC binds beta-catenin and is involved in the Axin complex, suggesting that APC regulates beta-catenin phosphorylation. 16798748 2006
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.100 Biomarker disease BEFREE APC binds to beta-catenin, a key component of the Wnt signalling pathway, and induces its degradation. 17143298 2006