Gene: TNKS ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8658
Gene Symbol: TNKS
TNKS 		0.040 Biomarker disease BEFREE APC truncating mutations in Middle Eastern Population: Tankyrase inhibitor is an effective strategy to sensitize APC mutant CRC To 5-FU chemotherapy. 31704613 2020
Entrez Id: 8658
Gene Symbol: TNKS
TNKS 		0.040 GeneticVariation disease BEFREE Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition. 31337618 2019
Entrez Id: 8658
Gene Symbol: TNKS
TNKS 		0.040 GeneticVariation disease BEFREE Survival of APC-mutant colorectal cancer cells requires interaction between tankyrase and a thiol peroxidase, peroxiredoxin II. 28683851 2017
Entrez Id: 8658
Gene Symbol: TNKS
TNKS 		0.040 GeneticVariation disease BEFREE Here the authors show that in colorectal cancers with APC mutation, PrxII binds to tankyrase and prevents its oxidative inactivation, thereby preventing Axin1-dependent degradation of ²b-catenin. 28659575 2017