Attenuated expression of menin and p27 (Kip1) in an aggressive case of multiple endocrine neoplasia type 1 (MEN1) associated with an atypical prolactinoma and a malignant pancreatic endocrine tumor.
A strong correlation between MLL and p27(Kip1) mRNA levels was observed in prolactinomas and growth hormone-secreting adenomas, and these levels were attenuated except in growth hormone-secreting adenomas treated with a somatostatin analogue, octreotide.