Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | Biomarker | group | BEFREE | The findings show that hepsin promotes invasive prostate tumor growth and metastasis and suggest that active site-directed hepsin inhibition could be effective in prostate cancer therapy. | 19843851 | 2009 | ||||
|
0.370 | Biomarker | group | LHGDN | Hepsin transgenic mice displayed reduced laminin-332 (Ln-332) expression in prostate tumors. | 18784072 | 2008 | ||||
|
0.370 | Biomarker | group | BEFREE | Direct cleavage of Ln-332 may be one mechanism by which hepsin promotes prostate tumor progression and metastasis, possibly by up-regulating prostate cancer cell motility. | 18784072 | 2008 | ||||
|
0.370 | GeneticVariation | group | LHGDN | Variants in the HEPSIN gene are associated with prostate cancer in men of European origin. | 16783571 | 2006 | ||||
|
0.370 | Biomarker | group | CTD_human | Variants in the HEPSIN gene are associated with prostate cancer in men of European origin. | 16783571 | 2006 | ||||
|
0.370 | AlteredExpression | group | BEFREE | Several studies have shown that hepsin mRNA is significantly elevated in most prostate tumors, as well as a significant fraction of ovarian and renal cell carcinomas and hepatomas. | 16585186 | 2006 | ||||
|
0.370 | Biomarker | group | LHGDN | Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2. | 15792801 | 2005 | ||||
|
0.370 | Biomarker | group | CTD_human | Analysis of candidate genes for prostate cancer. | 15583422 | 2004 | ||||
|
0.370 | AlteredExpression | group | LHGDN | Hepsin and maspin are inversely expressed in laser capture microdissectioned prostate cancer. | 12629351 | 2003 | ||||
|
0.370 | AlteredExpression | group | BEFREE | Some, such as hepsin, not only show increased expression in cancer, but can also provide prognostic information on prostate tumors based on their level of expression. | 12172426 | 2002 |