Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker group BEFREE The present study examined the influence of paracrine IL-6 signaling on prostate tumor growth using allograft models of mouse prostate cancer (TRAMP-C2), colon cancer (MC38), and melanoma (B16) cell lines in wildtype (WT) and IL-6 knockout (IL-6<sup>-/-</sup> ) mice. 30345534 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression group BEFREE <b>Principal conclusions</b>: Taken together, our results argue that CXCL1 plays an important role in sustaining the growth of bladder and prostate tumors via up-regulation of IL6 and down-regulation of TIMP4. 30809313 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker group BEFREE In this context, the anti-IL-6 antibody siltuximab (CNTO 328) has been demonstrated to inhibit growth of prostate tumors in vitro and in vivo and delays progression towards castration resistance. 28315704 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression group BEFREE Determination of the expression and localization of IL-6 and IGF-1Ec in prostate tumors was examined by qRT-PCR and by IHC. 30134795 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression group BEFREE Immunohistochemistry studies showed increased levels of STAT3 and IL-6, but low levels of programmed cell death protein 4 (PDCD4), in prostate tumor epithelial cells compared to adjacent perinormal prostate epithelial cells. 28467474 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker group BEFREE With this model, we demonstrate that IL-6 induces prostate neoplasm autonomously. 28077171 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression group BEFREE ESE3/EHF and IL-6 were significantly inversely correlated in prostate tumors. 27732936 2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Therapeutic group CTD_human Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition. 25970160 2015
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker group CTD_human Niclosamide suppresses cell migration and invasion in enzalutamide resistant prostate cancer cells via Stat3-AR axis inhibition. 25970160 2015
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression group BEFREE Serum IL-6 levels also correlate with prostate tumor burden, prostate-specific antigen levels and metastasis. 24446297 2014
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker group BEFREE IL-6 can convert non-ALDH(high) cells to ALDH(high) cells in prostate cancer cell line as well as from cells derived from human prostate tumors, the conversion mediated by IL-6 was abrogated in the presence of STAT3 inhibitor or upon STAT3 knockdown. 25261365 2014
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker group BEFREE Observations of the clinical behaviour of prostate tumors suggest that the increased secretion of IL-6 and CCL5 and the higher expression of PSMA may be correlated. 19242540 2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker group LHGDN Annexin A2 positively contributes to the malignant phenotype and secretion of IL-6 in DU145 prostate cancer cells. 18924133 2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Therapeutic group CTD_human Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor. 19011039 2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker group LHGDN The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth. 19147545 2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Therapeutic group CTD_human Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2. 19240160 2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker group CTD_human Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor. 19011039 2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker group CTD_human Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2. 19240160 2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker group LHGDN Interleukin-6 activates PI3K/Akt pathway and regulates cyclin A1 to promote prostate cancer cell survival. 18027847 2008
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression group LHGDN Depletion of intracellular zinc increases expression of tumorigenic cytokines VEGF, IL-6 and IL-8 in prostate cancer cells via NF-kappaB-dependent pathway. 18615482 2008
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 AlteredExpression group LHGDN Hepatocyte growth factor and interleukin-6 in combination with prostate volume are possible prostate cancer tumor markers in patients with gray-zone PSA levels. 17876341 2008
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker group CTD_human p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion. 17196171 2007
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker group LHGDN p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion. 17196171 2007
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Biomarker group LHGDN Interleukin-6 undergoes transition from growth inhibitor associated with neuroendocrine differentiation to stimulator accompanied by androgen receptor activation during LNCaP prostate cancer cell progression. 17373716 2007
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.400 Therapeutic group CTD_human p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion. 17196171 2007