Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.070 | Biomarker | group | BEFREE | Treatment with the specific PI3K inhibitor GDC0941 resulted in responses very similar between syngeneic MuCaP and primary Pten KO prostate tumors. | 30133757 | 2018 | ||||
|
0.070 | Biomarker | group | BEFREE | Behavioral stress inhibited apoptosis and delayed prostate tumor involution both in phosphatase and tensin homolog-deficient (PTEN-deficient) prostate cancer xenografts treated with PI3K inhibitor and in prostate tumors of mice with prostate-restricted expression of c-MYC (Hi-Myc mice) subjected to androgen ablation therapy with bicalutamide. | 23348742 | 2013 | ||||
|
0.070 | Biomarker | group | BEFREE | Similarly, IGF-I suppressed BMP4-induced transcription of the Id1, Id2, and Id3 genes that are crucially involved in prostate tumor progression through PI3K-dependent and mTORC1/2-dependent mechanisms. | 21062988 | 2010 | ||||
|
0.070 | GeneticVariation | group | BEFREE | Overall, 13 of the 40 (33%) prostate tumors had alterations in the PI3K pathway. | 19443396 | 2009 | ||||
|
0.070 | AlteredExpression | group | BEFREE | We investigated the role of the PI3K-Akt signaling pathway in the invasion of prostate cancer cell lines and activation of this pathway in primary human prostate tumors. | 17551921 | 2007 | ||||
|
0.070 | AlteredExpression | group | LHGDN | We investigated the role of the PI3K-Akt signaling pathway in the invasion of prostate cancer cell lines and activation of this pathway in primary human prostate tumors. | 17551921 | 2007 | ||||
|
0.070 | Biomarker | group | BEFREE | These data show that apoptosis induced by blockade of the PI3K pathway in prostate tumor cells is mediated by an autocrine Fas/FasL apoptotic mechanism and the Fas apoptotic pathway is both necessary and sufficient to mediate apoptosis by PI3K inhibition. | 16651432 | 2006 | ||||
|
0.070 | Biomarker | group | LHGDN | Requirement for NF-(kappa)B in interleukin-4-induced androgen receptor activation in prostate cancer cells. | 15678501 | 2005 |