Gene: PTGS2 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE Here, using cellular and mouse models, we showed that PKCε overexpression acts synergistically with Pten loss to promote NF-κB activation and induce cyclooxygenase-2 (COX-2) expression, phenotypic traits which are also observed in human prostate tumors. 29765153 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 GeneticVariation group BEFREE The aim of this study was to evaluate the association of polymorphic genotypes in the cyclooxygenase 2 gene (COX2), which is reported to be overexpressed in prostate tumors, with Taiwan prostate cancer patients. 21273602 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE Evidence indicates that COX-2 plays a role in carcinogenesis and that it is overexpressed in prostate tumors. 22023987 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group BEFREE Evidence indicates that COX-2 plays a role in carcinogenesis and that it is over-expressed in prostate tumours. 18974063 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 GeneticVariation group LHGDN Evidence indicates that COX-2 plays a role in carcinogenesis and that it is over-expressed in prostate tumours. 18974063 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Translationally regulated C/EBP beta isoform expression upregulates metastatic genes in hormone-independent prostate cancer cells. 18512730 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 GeneticVariation group LHGDN Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies. 17999989 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Vasoactive intestinal peptide induces cyclooxygenase-2 expression through nuclear factor-kappaB in human prostate cell lines Differential time-dependent responses in cancer progression. 17434257 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 GeneticVariation group LHGDN COX2 genetic variation, NSAIDs, and advanced prostate cancer risk. 17609663 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group CTD_human COX2 genetic variation, NSAIDs, and advanced prostate cancer risk. 17609663 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 GeneticVariation group LHGDN Genetic variation in the COX-2 gene and the association with prostate cancer risk. 16506214 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group BEFREE Our findings suggest that blockage of osteopontin and/or COX-2 is a promising therapeutic approach for the inhibition of prostate tumor progression and angiogenesis. 16818637 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group CTD_human Genetic variation in the COX-2 gene and the association with prostate cancer risk. 16506214 2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line. 15550400 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group LHGDN Cyclooxygenase-2 expression correlates with local chronic inflammation and tumor neovascularization in human prostate cancer. 15867220 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group CTD_human Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate model. 15126378 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group CTD_human COX-2 gene promoter haplotypes and prostate cancer risk. 14754878 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 GeneticVariation group LHGDN COX-2 gene promoter haplotypes and prostate cancer risk. 14754878 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group LHGDN Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells. 11959891 2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 AlteredExpression group LHGDN Saw palmetto berry extract inhibits cell growth and Cox-2 expression in prostatic cancer cells. 11913955 2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.400 Biomarker group CTD_human The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. 10753955 2000