Gene: CXCR4 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		0.100 AlteredExpression group BEFREE The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells. 29396484 2018
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		0.100 AlteredExpression group BEFREE CXCR4 mRNA overexpression in high grade prostate tumors: lack of association with TMPRSS2-ERG rearrangement. 23321466 2013
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		0.100 Biomarker group BEFREE These findings support the development of novel therapeutics targeting the CXCL12/CXCR4 axis as an ancillary to those targeting the androgen/AR axis to effectively treat castration resistant/recurrent prostate tumors. 22245379 2012
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		0.100 AlteredExpression group LHGDN Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer. 18201276 2008
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		0.100 Biomarker group LHGDN Establishment of CXCR4-small interfering RNA retrovirus vector driven by human prostate-specific antigen promoter and its biological effects on prostate cancer in vitro and in vivo. 18431597 2008
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		0.100 Biomarker group LHGDN CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone. 18337451 2008
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		0.100 AlteredExpression group LHGDN CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12. 16114056 2006
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		0.100 AlteredExpression group LHGDN Androgen receptor negatively influences the expression of chemokine receptors (CXCR4, CCR1) and ligand-mediated migration in prostate cancer DU-145. 16969502 2006
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		0.100 Biomarker group LHGDN CXCR4 and CXCL12 (SDF-1) in prostate cancer: inhibitory effects of human single chain Fv antibodies. 15328206 2004
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		0.100 Biomarker group LHGDN CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. 15467730 2004
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		0.100 Biomarker group LHGDN The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis. 15844659 2004
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		0.100 AlteredExpression group LHGDN Similar effects of CXCR4 overexpression on tumor growth in vivo were also noted in two breast cancer lines, suggesting that the observed effect of CXCR4 is not unique to prostate tumor cells. 15180966 2004
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		0.100 AlteredExpression group LHGDN Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo. 12761880 2003
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4 		0.100 AlteredExpression group LHGDN Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. 11912162 2002