Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element. 23990973 2013
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE Certain HLA-B and HLA-C alleles confer susceptibility to PsA among patients with psoriasis and may be used to identify patients with PsC who may develop PsA. 21900282 2012
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE And it is interesting that a missense mutation in SPRED1 and a splice region mutation in C3 are found in the psoriasis individuals in the other two MZ twin pairs without carrying HLA-C*0602 allele. 31629629 2020
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE : No allele was associated with absence of recurrence in patients receiving adjuvant interferon with the exception of HLA-Cw 06, an allele correlated with psoriasis. 20549830 2010
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE HLA-C alleles of 89 patients with psoriasis with onset at the age of 40 y or later and 80 control subjects were determined by a polymerase chain reaction (PCR), low-resolution method. 17666781 2007
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease LHGDN Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. 19169254 2009
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE Patients who carried the HLA-Cw*06 allele had a significantly earlier mean age of onset of both psoriasis (P = 0.01) and arthritis (P = 0.008) compared with Cw*06-negative patients. 16313304 2005
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE These data demonstrate the power of SNP haplotype-based association analyses and provide high-resolution dissection of genetic variation across the PSORS1 interval, the major susceptibility locus for psoriasis. 12148091 2002
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE The presence of <i>HLA-C*06</i> or rs26653 G allele significantly increased the risk of psoriasis by 2.4 times or twice, respectively. 30008647 2018
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE Furthermore, when combining the results of both the stepwise regression analysis and the HLA-C*06:02 conditioning analysis, different variants were found to be independently associated with each psoriasis subgroup. 29076194 2017
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE Very recent data strongly indicate that HLA-Cw*0602 is the susceptibility allele in this locus, a finding that is consistent with the notion that the pathogenesis of psoriasis involves autoantigen recognition by epidermal CD8+ T lymphocytes. 18021893 2008
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE Mapping of the major psoriasis-susceptibility locus (PSORS1) in a 70-Kb interval around the corneodesmosin gene (CDSN). 15529278 2005
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE Fine mapping of the psoriasis susceptibility gene PSORS1: a reassessment of risk associated with a putative risk haplotype lacking HLA-Cw6. 15854032 2005
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE Although a psoriasis susceptibility gene(s) has not been yet identified, a number of candidate genes were studied, with evidence for a major locus located within the major histocompatibility complex (PSORS 1). 16314826 2005
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE Moreover, we need to determine allele-specific effects of ERAP1 variants in the context of HLA-B*51 and HLA-Cw*6, which are associated with Behçet's disease and psoriasis, respectively. 26002027 2015
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE Adjustment for age, sex, asthma and a PSORS1 SNP associated with psoriasis in the EGEA data did not change the significance of these associations. 18560587 2008
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE I review two examples of such challenges: the cloning of GPR154 (GPRA) and AAA1 on chromosome 7p14 at a susceptibility locus for atopy and asthma, and the study of HLA-Cw6, CCHCR1 (HCR) and CDSN on chromosome 6p21 at PSORS1, the major susceptibility locus for psoriasis. 16096103 2005
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE Similar to AS, the strongest genetic signal of susceptibility to psoriasis and psoriatic arthritis also emanates from the MHC region (attributable mostly to HLA-C(*)06:02 although other genes have been implicated), and gene-gene interaction of HLA-C with ERAP1. 22487796 2012
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE After adjusting for significant HLA-B and HLA-C alleles in multivariate analyses, MICA*016 remained significantly associated with psoriasis [odds ratio (OR) = 5.5, P = 0.008]. 21457151 2011
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE There are several susceptibility genes for psoriasis residing in chromosome 6p near the HLA-C locus, including the corneodesmosin (CDSN) gene, the octamer transcription factor-3 (POU5F1) gene, the major histocompatibility complex class I chain-related gene A (MICA), and the gene for tumour necrosis factor (TNF)-alpha. 12653732 2003
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE We sought to test whether HLA-C*06:02, the primary genetic susceptibility allele for psoriasis, predisposes patients to respond differently to the 2 most commonly prescribed biologics for psoriasis: adalimumab (anti-TNF-α) and ustekinumab (anti-IL-12/23). 30578879 2019
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE PSORS1C2 is a gene located between coiled-coil alpha-helical rod protein 1 (CCHCR1) and corneodesmosin (CDSN) within the psoriasis susceptibility locus 1 (PSORS1). 27943452 2017
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE This includes several HLA class I alleles associated with HIV-1 control; amino acid residues at HLA-B positions 67, 70, and 97 that mediate HIV-1 peptide binding; and the deletion polymorphism rs67384697 associated with high surface expression of HLA-C. We also found that the compound genotype KIR3DS1 plus HLA-B Bw4-80I, which respectively encode a natural killer cell activating receptor and its putative ligand, significantly increased psoriasis susceptibility. 22577363 2012
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE Significant associations were found for paediatric-onset psoriasis with ERAP1 (p = 0.002), IL23R (p = 0.01), LCE3C_LCE3B-del (p = 0.00049) and HLA-C*06 (p = 3.15 × 10(-30)). 24791935 2014
Entrez Id: 3107
Gene Symbol: HLA-C
HLA-C
0.400 GeneticVariation disease BEFREE More importantly we find that rs9468925 in HLA-C/HLA-B is associated with both psoriasis and vitiligo, providing first important evidence that two major skin diseases share a common genetic locus in the MHC, and a basis for elucidating the molecular mechanism of skin disorders. 22125590 2011