Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease BEFREE The TRAF3IP2 gene resides within one of at least 63 psoriasis susceptibility loci and encodes Act1, an adapter protein involved in IL-17 receptor and CD40 signaling pathways. 29302052 2019
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 Biomarker disease BEFREE Consistently, many psoriasis susceptibility genes encode the TRAF6 signaling players, such as ACT1 (<i>TRAF3IP2</i>), A20 (<i>TNFAIP3</i>), ABIN1 (<i>TNIP1</i>), IL-36Ra (<i>IL36RN</i>), IkappaBzeta (<i>NFKBIZ</i>), and CARD14. 31156649 2019
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease BEFREE Collectively, these results implicate NETs and the Act1 D10N variant in human Th17 induction from peripheral blood mononuclear cells, with ramifications for immunogenetic studies of psoriasis and other autoimmune diseases. 30528823 2019
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease BEFREE A report in the June 2019 issue of the Journal of Investigative Dermatology reveals a role of neutrophil extracellular traps (NETs) in the induction of T helper type 17 cell responses and shows the relevance of this pathway in patients with psoriasis carrying a common risk variant in the TRAF3IP2 gene (Lambert et al., 2019). 31230639 2019
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease BEFREE Candidate long-range regulatory sites acting on the IL17 pathway genes TRAF3IP2 and IL17RA are associated with psoriasis. 30076642 2018
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 Biomarker disease BEFREE Act1: A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes. 28390815 2017
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 Biomarker disease BEFREE These findings suggest that TRAF3IP2 may alter both epidermal homeostasis and keratinocyte defense responses to influence psoriasis risk. 28274739 2017
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease GWASCAT Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. 25903422 2015
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease BEFREE In the last years TRAF3IP2 gene variants had been described as associated with susceptibility to several diseases such as psoriasis and psoriatic arthritis. 25775161 2015
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease BEFREE A missense single nucleotide polymorphism (rs33980500; SNP-D10N) that resulted in the substitution of an asparagine for an aspartic acid at position 10 of ACT1 (ACT1-D10N) is associated with psoriasis susceptibility. 25024377 2014
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease BEFREE We identified the missense variant rs2303138 (p.Ala763Thr) within the LNPEP gene associated with psoriasis (Pcombined=1.83 × 10(-13), odds ratio=1.16) and validated four previously reported genes: IL28RA, NFKBIA, TRAF3IP2, and CARD14 (9.74 × 10(-11)P9.37 × 10(-5)), which confirmed the involvement of the nuclear factor-κB signaling pathway in psoriasis pathogenesis. 23897274 2014
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease BEFREE We have replicated the association of TRAF3IP2-_rs33980500 variant with the susceptibility to psoriasis. 24005976 2014
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 Biomarker disease BEFREE Genome-wide association (GWA) studies recently identified a novel gene, TRAF3IP2, involved in the susceptibility to psoriasis. 22445837 2013
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 Biomarker disease BEFREE TRAF3IP2 gene, associated with susceptibility to psoriatic arthritis and psoriasis, encodes for Act1, a negative regulator of adaptive immunity and a positive signaling adaptor in IL-17-mediated immune responses. 23836313 2013
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease BEFREE In the absence of IL-17 signaling, IL-22 was the main contributor to skin inflammation, which provides a molecular mechanism for the association of Act1(D10N) with psoriasis susceptibility. 23202271 2013
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 Biomarker disease BEFREE CIKS/Act1-mediated signaling by IL-17 cytokines in context: implications for how a CIKS gene variant may predispose to psoriasis. 22581863 2012
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease GWASDB Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. 23143594 2012
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease GWASCAT Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. 23143594 2012
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 Biomarker disease CTD_human Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. 20953186 2010
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease BEFREE Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. 20953188 2010
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 Biomarker disease CTD_human Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. 20953188 2010
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease GWASDB Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. 20953188 2010
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 Biomarker disease CTD_human A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. 20953190 2010
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease BEFREE Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. 20953186 2010
Entrez Id: 10758
Gene Symbol: TRAF3IP2
TRAF3IP2
0.500 GeneticVariation disease GWASCAT Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. 20953188 2010