TRAF3IP2
|
0.500 |
Biomarker
|
disease |
BEFREE |
TRAF3IP2 gene, associated with susceptibility to psoriatic arthritis and psoriasis, encodes for Act1, a negative regulator of adaptive immunity and a positive signaling adaptor in IL-17-mediated immune responses.
|
23836313 |
2013 |
TRAF3IP2
|
0.500 |
Biomarker
|
disease |
BEFREE |
Act1: A Psoriasis Susceptibility Gene Playing its Part in Keratinocytes.
|
28390815 |
2017 |
TRAF3IP2
|
0.500 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
|
20953190 |
2010 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A missense single nucleotide polymorphism (rs33980500; SNP-D10N) that resulted in the substitution of an asparagine for an aspartic acid at position 10 of ACT1 (ACT1-D10N) is associated with psoriasis susceptibility.
|
25024377 |
2014 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A report in the June 2019 issue of the Journal of Investigative Dermatology reveals a role of neutrophil extracellular traps (NETs) in the induction of T helper type 17 cell responses and shows the relevance of this pathway in patients with psoriasis carrying a common risk variant in the TRAF3IP2 gene (Lambert et al., 2019).
|
31230639 |
2019 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Candidate long-range regulatory sites acting on the IL17 pathway genes TRAF3IP2 and IL17RA are associated with psoriasis.
|
30076642 |
2018 |
TRAF3IP2
|
0.500 |
Biomarker
|
disease |
BEFREE |
CIKS/Act1-mediated signaling by IL-17 cytokines in context: implications for how a CIKS gene variant may predispose to psoriasis.
|
22581863 |
2012 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Collectively, these results implicate NETs and the Act1 D10N variant in human Th17 induction from peripheral blood mononuclear cells, with ramifications for immunogenetic studies of psoriasis and other autoimmune diseases.
|
30528823 |
2019 |
TRAF3IP2
|
0.500 |
Biomarker
|
disease |
CTD_human |
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.
|
20953186 |
2010 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.
|
20953186 |
2010 |
TRAF3IP2
|
0.500 |
Biomarker
|
disease |
BEFREE |
Consistently, many psoriasis susceptibility genes encode the TRAF6 signaling players, such as ACT1 (<i>TRAF3IP2</i>), A20 (<i>TNFAIP3</i>), ABIN1 (<i>TNIP1</i>), IL-36Ra (<i>IL36RN</i>), IkappaBzeta (<i>NFKBIZ</i>), and CARD14.
|
31156649 |
2019 |
TRAF3IP2
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genome-wide association (GWA) studies recently identified a novel gene, TRAF3IP2, involved in the susceptibility to psoriasis.
|
22445837 |
2013 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
|
20953188 |
2010 |
TRAF3IP2
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
|
20953188 |
2010 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
|
20953188 |
2010 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
|
20953188 |
2010 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.
|
25903422 |
2015 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the absence of IL-17 signaling, IL-22 was the main contributor to skin inflammation, which provides a molecular mechanism for the association of Act1(D10N) with psoriasis susceptibility.
|
23202271 |
2013 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the last years TRAF3IP2 gene variants had been described as associated with susceptibility to several diseases such as psoriasis and psoriatic arthritis.
|
25775161 |
2015 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The TRAF3IP2 gene resides within one of at least 63 psoriasis susceptibility loci and encodes Act1, an adapter protein involved in IL-17 receptor and CD40 signaling pathways.
|
29302052 |
2019 |
TRAF3IP2
|
0.500 |
Biomarker
|
disease |
BEFREE |
These findings suggest that TRAF3IP2 may alter both epidermal homeostasis and keratinocyte defense responses to influence psoriasis risk.
|
28274739 |
2017 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We have replicated the association of TRAF3IP2-_rs33980500 variant with the susceptibility to psoriasis.
|
24005976 |
2014 |
TRAF3IP2
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We identified the missense variant rs2303138 (p.Ala763Thr) within the LNPEP gene associated with psoriasis (Pcombined=1.83 × 10(-13), odds ratio=1.16) and validated four previously reported genes: IL28RA, NFKBIA, TRAF3IP2, and CARD14 (9.74 × 10(-11)P9.37 × 10(-5)), which confirmed the involvement of the nuclear factor-κB signaling pathway in psoriasis pathogenesis.
|
23897274 |
2014 |