Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease MGD
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Thus, targeting Stat3 may be potentially therapeutic in the treatment of psoriasis. 15592573 2005
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 AlteredExpression disease BEFREE All psoriasis lesions also had detectable levels of activated Stat3, a protein indicated in development of the disease, whereas control tissue lacked this protein. 16417229 2006
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Phosphorylation of STAT3 was also assessed in lesional skin of CTCL and psoriasis by immunohistochemistry. 22048239 2011
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE We identified seven susceptibility loci outside the human leukocyte antigen region (9p24 near JAK2, 10q22 at ZMIZ1, 11q13 near PRDX5, 16p13 near SOCS1, 17q21 at STAT3, 19p13 near FUT2, and 22q11 at YDJC) shared between PS and CD with genome-wide significance (p < 5 × 10(-8)) and confirmed four already established PS and CD risk loci (IL23R, IL12B, REL, and TYK2). 22482804 2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease CTD_human Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. 23143594 2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE It has been demonstrated that epidermal Stat3 activation is required for psoriasis development, since keratinocyte-specific Stat3 activation in a mouse model elicits a psoriasis-like phenotype, which is reversed by inhibition of Stat3 signaling. 23870655 2013
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 AlteredExpression disease BEFREE Studies of Jak/STAT3 expression and signalling in psoriasis identifies STAT3-Ser727 phosphorylation as a modulator of transcriptional activity. 23614738 2013
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 AlteredExpression disease BEFREE We further show that overexpression of hsa-miR-4516 downregulates STAT3, p-STAT3, CDK6, and UBE2N proteins that are consistently upregulated in psoriasis and induces apoptosis in HaCaT cells. 24610393 2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Collectively, our study indicated that CAV-1 participates in the pathogenesis of psoriasis by regulating the STAT3 pathway and cytokine networks. 26134945 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 AlteredExpression disease BEFREE The level of STAT3 mRNA and pSTAT3 was higher, but let-7a expression was lower in the psoriasis group than the control group. 28494466 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 AlteredExpression disease BEFREE Several mouse models of psoriasis including drug-induced models (topical application of imiquimod to the skin) and genetically engineered mice (constitutive activation of epidermal STAT3, epidermal deletion of JunB/c-Jun, and epidermal overexpression of Tie2) have been used to study the pathophysiology of the disease; however such models cannot fully recapitulate all molecular and cellular pathways occurring in human psoriasis. 28063039 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 AlteredExpression disease BEFREE We also found that IL-22 increases CD147 transcription in vitro and in vivo and that Stat3 binds directly to the CD147 promoter between positions -854 and -440, suggesting that CD147 expression is up-regulated in patients with psoriasis through Stat3 activation. 28272440 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 GeneticVariation disease BEFREE rs744166GG in STAT3 and rs7574865TT in STAT4 had higher frequencies in the case than the control group, suggesting these 2 genotypes increase the susceptibility to psoriasis (p < 0.05). 28420002 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Our data suggest that systemic IL-23/STAT3 axis is responsible for enhanced airway inflammation during psoriasis. 27984001 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Silencing the target gene STAT3 in psoriatic KCs with siRNA combined with ultrasonic irradiation and microbubbles would contribute to a significant innovation as a new clinical therapy for psoriasis. 30127220 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 GeneticVariation disease BEFREE Psoriasis: A STAT3-Centric View. 29316631 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 AlteredExpression disease BEFREE It was observed that 'psoriasis 1' downregulated the concentrations of TNF‑α, IFN‑γ, IL‑22, IL‑17C, IL‑1β and IL‑4, and upregulated the concentration of 25HVD3; furthermore, 'psoriasis 1' downregulated the expression levels of NF‑κB, phosphorylated (p)‑NF‑κB, IKK, p‑IKK, STAT3, p‑STAT3, STAT4 and p‑STAT4, and upregulated the expression level of VDR in TNF‑α‑induced HaCaT cells. 30015892 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Taken together, our findings indicated that the curative effects of CTS on psoriasis are accomplished mainly through modulating STAT3, which providing evidences to develop CTS as a potential therapeutic agent for patients with psoriasis. 29427477 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 AlteredExpression disease BEFREE STAT3 was overexpressed in the intestinal mucosa of active and non-active IBD, and a similar upregulation was seen in skin biopsies from EN [84.7 vs 22.3, p < 0.001] and PG [60.5 vs 22.3, p = 0.011], but not in psoriasis. 29182760 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE The IL-22-STAT3-Bcl-3 pathway may be important in the pathogenesis of psoriasis. 28901004 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Using a preclinical model of psoriasis, we show that intradermal injection of APTstat3 tagged with a 9-arginine cell-penetrating peptide (APTstat3-9R) reduced disease progression and modulated psoriasis-related cytokine signaling through inhibition of STAT3 phosphorylation. 29949348 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Our findings indicate that miR-320b negatively regulates NHEK proliferation by targeting AKT3 to regulate the STAT3 and SAPK/JNK signaling pathways and might participate in the pathogenesis of psoriasis in Chinese Han populations. miR-320b may also be a novel diagnostic marker or therapeutic target for this disease. 30136020 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Together, our results reveal a novel regulatory mechanism of IL-22 expression by STAT1 through directly antagonizing STAT3, and the importance of the balance between STAT3 and STAT1 in IL-22 regulation and psoriasis pathogenesis. 29750958 2018