Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. 21242515 2011
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE These findings suggest that the inflammatory milieu in the epidermal microenvironment in psoriasis is more likely dependent on evolutionarily ancient cytokines such as IL-1, rather than those of the adaptive immune response. 17591951 2007
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE The profound and complex changes in this system suggest IL-1 dysregulation may be integrally involved in the inflammatory, biochemical, and proliferative processes involved in the pathophysiology of psoriasis. 2191038 1990
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE We observed that keratinocytes were primed to secrete IL-1β when cultured in conditions mimicking psoriasis. 30571969 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE Among LL37-inducible genes, IL-1 cluster genes, particularly IL36G, are of interest because we observed coordinate increases in CAMP and IL-36γ in the lesional skin of psoriasis, whereas virtually no CAMP or IL-36γ was observed in nonlesional skin and normal skin. 25305315 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 AlteredExpression disease BEFREE Only a few genes were differentially induced in psoriasis (CLEC7A (dectin-1), Toll-like receptor (TLR) 4, and mannose receptor C type 1 (MRC1)) or AD (MRC1, IL1RN, and IL1β) compared with normal epidermis. 20631729 2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE There are over 300,000 patients worldwide being treated with agents that specifically block the biological activities of interleukin-1 (IL-1) or tumor necrosis factor (TNF) for reducing the severity of autoimmune diseases such as rheumatoid arthritis, Crohn's disease or psoriasis. 12763679 2003
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE Promoter polymorphisms of the genes encoding tumor necrosis factor-alpha and interleukin-1beta are associated with different subtypes of psoriasis characterized by early and late disease onset. 11851889 2002
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE For example, in asthma, both IL-33 and IL-1 are of major importance, as are IL-36 and IL-1 in psoriasis. 31427775 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE IL-1β is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis. 28422993 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE The IL-1 family member cytokine IL-36γ is recognised as key mediator in the immunopathology of psoriasis, hallmarks of which involve the activation of both resident and infiltrating inflammatory myeloid cells and aberrant angiogenesis. 29535706 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE To determine what role the IL-1 system might contribute to the inflammatory process in psoriasis, semi-quantitative RT-PCR and cRNA microarray studies were performed on biopsies excised from lesional and non-lesional skin. 16460958 2006
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 AlteredExpression disease BEFREE We tested their effectiveness in the treatment of psoriasis in order to further investigate the potential topical anti-inflammatory activity of polyphenols by means of a randomized, double-blind, placebo-controlled add-on clinical trial, after having examined their ability to downregulate the expression of IL-1β cytokine in monocyte/macrophage primary cell culture. 29441952 2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE In the present study, we investigated IL-1 family members in psoriasis and the effects of vitD and retinoic acid (RA) on these members. 23435685 2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 AlteredExpression disease BEFREE To better understand the cellular target(s) of cyclosporin action in psoriasis, we have studied the effects of systemic short-term (7 d), low-dose (3-7.5 mg/kg) cyclosporin A administration on the expression of the cytokines interleukin (IL)-8 and IL-1 beta in psoriatic lesions. 8245502 1993
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE PK2 promoted KC and macrophage to produce interleukin-1 (IL-1), the central player of inflammation and psoriasis, which acts on adjacent fibroblast to induce inflammatory cascades and KC hyperproliferation. 27887936 2016
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE To thoroughly study the IL-1 system in psoriasis, we semiquantitatively analyzed the expression of all currently characterized IL-1 isoforms and their receptors in parallel in both lesional (PP) and nonlesional psoriatic (PN) epidermis. 9058835 1997
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE Diacerein may have therapeutic applications to diminish IL-1-induced skin inflammation in psoriasis and attenuate IL-1-induced development of atherosclerosis. 28323859 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE CCN1 promotes IL-1β production in keratinocytes by activating p38 MAPK signaling in psoriasis. 28266627 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE A Critical Role of the IL-1β-IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis. 30120937 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE The IL-1 gene complex may play a role in the development of PsA and/or psoriasis or act as a marker for other genes on chromosome 2q12 to 2q13. 12890860 2004
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE Accumulating evidence indicates that IL-1 family members and Th17 cytokines have a pathogenic role in psoriasis. 21881584 2011
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE We propose that activation of MAPK by integrins, either directly or through increased IL-1alpha production, is responsible for epidermal hyperproliferation in psoriasis and wound healing, and that the sporadic phenotype of the transgenic mice may reflect the complex mechanisms by which IL-1 release and responsiveness are controlled in skin. 11518726 2001
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE The IL-1 family member IL-36α has proinflammatory and pathogenic properties in psoriasis. 28857172 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE The IL-1 super-family of cytokines and receptors is highly pleiotropic and plays a fundamental role in the pathogenesis of several auto-inflammatory conditions including rheumatoid arthritis, multiple sclerosis and psoriasis. 31231388 2019