Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE The profound and complex changes in this system suggest IL-1 dysregulation may be integrally involved in the inflammatory, biochemical, and proliferative processes involved in the pathophysiology of psoriasis. 2191038 1990
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE Using cryostat skin sections and an IL-1 beta-specific monoclonal antibody (MoAb) in an indirect immunoperoxidase technique, a diffuse staining in the entire epidermis was observed in sections of uninvolved skin from psoriasis patients. 2258628 1990
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease CTD_human Increased mRNA expression of manganese superoxide dismutase in psoriasis skin lesions and in cultured human keratinocytes exposed to IL-1 beta and TNF-alpha. 7744320 1995
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE Increased mRNA expression of manganese superoxide dismutase in psoriasis skin lesions and in cultured human keratinocytes exposed to IL-1 beta and TNF-alpha. 7744320 1995
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 AlteredExpression disease BEFREE To better understand the cellular target(s) of cyclosporin action in psoriasis, we have studied the effects of systemic short-term (7 d), low-dose (3-7.5 mg/kg) cyclosporin A administration on the expression of the cytokines interleukin (IL)-8 and IL-1 beta in psoriatic lesions. 8245502 1993
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE To thoroughly study the IL-1 system in psoriasis, we semiquantitatively analyzed the expression of all currently characterized IL-1 isoforms and their receptors in parallel in both lesional (PP) and nonlesional psoriatic (PN) epidermis. 9058835 1997
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE We propose that activation of MAPK by integrins, either directly or through increased IL-1alpha production, is responsible for epidermal hyperproliferation in psoriasis and wound healing, and that the sporadic phenotype of the transgenic mice may reflect the complex mechanisms by which IL-1 release and responsiveness are controlled in skin. 11518726 2001
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE Promoter polymorphisms of the genes encoding tumor necrosis factor-alpha and interleukin-1beta are associated with different subtypes of psoriasis characterized by early and late disease onset. 11851889 2002
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE There are over 300,000 patients worldwide being treated with agents that specifically block the biological activities of interleukin-1 (IL-1) or tumor necrosis factor (TNF) for reducing the severity of autoimmune diseases such as rheumatoid arthritis, Crohn's disease or psoriasis. 12763679 2003
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE The IL-1 gene complex may play a role in the development of PsA and/or psoriasis or act as a marker for other genes on chromosome 2q12 to 2q13. 12890860 2004
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE To determine what role the IL-1 system might contribute to the inflammatory process in psoriasis, semi-quantitative RT-PCR and cRNA microarray studies were performed on biopsies excised from lesional and non-lesional skin. 16460958 2006
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE These findings suggest that the inflammatory milieu in the epidermal microenvironment in psoriasis is more likely dependent on evolutionarily ancient cytokines such as IL-1, rather than those of the adaptive immune response. 17591951 2007
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 AlteredExpression disease BEFREE Only a few genes were differentially induced in psoriasis (CLEC7A (dectin-1), Toll-like receptor (TLR) 4, and mannose receptor C type 1 (MRC1)) or AD (MRC1, IL1RN, and IL1β) compared with normal epidermis. 20631729 2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. 21242515 2011
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE Accumulating evidence indicates that IL-1 family members and Th17 cytokines have a pathogenic role in psoriasis. 21881584 2011
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE The contribution of IL-1β in the pathogenesis of psoriasis is well recognized. 23171454 2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE In the present study, we investigated IL-1 family members in psoriasis and the effects of vitD and retinoic acid (RA) on these members. 23435685 2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 AlteredExpression disease BEFREE In conclusion, changes in the expression of IL-1 receptors in psoriatic regulatory and effector T cells could contribute to the pathogenesis of psoriasis. 24665164 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE Among LL37-inducible genes, IL-1 cluster genes, particularly IL36G, are of interest because we observed coordinate increases in CAMP and IL-36γ in the lesional skin of psoriasis, whereas virtually no CAMP or IL-36γ was observed in nonlesional skin and normal skin. 25305315 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE Overexpression of the major epidermal proinflammatory cytokines interleukin (IL) 1 alpha (IL-1α) and 1 beta (IL-1β) is positively correlated with symptom exacerbation and disease progression in psoriasis, atopic dermatitis, neutrophilic dermatoses, skin phototoxicity, and skin cancer. 27604144 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE PK2 promoted KC and macrophage to produce interleukin-1 (IL-1), the central player of inflammation and psoriasis, which acts on adjacent fibroblast to induce inflammatory cascades and KC hyperproliferation. 27887936 2016
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE CCN1 promotes IL-1β production in keratinocytes by activating p38 MAPK signaling in psoriasis. 28266627 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE Diacerein may have therapeutic applications to diminish IL-1-induced skin inflammation in psoriasis and attenuate IL-1-induced development of atherosclerosis. 28323859 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 Biomarker disease BEFREE IL-1β is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis. 28422993 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.400 AlteredExpression disease BEFREE The results suggest that genetic variants related to increased IL-1β levels may be unfavorable when treating psoriasis with either anti-TNF or ustekinumab, whereas genetic variants related to high interferon-γ levels may be favorable when treating psoriasis with ustekinumab. 28696418 2018