Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE In conclusion, our results highlight the TRIM27 expression significantly increased by IL-6 and suggest a TRIM27/STAT3-dependent mechanism for regulation of inflammation and proliferation-associated development of psoriasis. 31747314 2020
Entrez Id: 79092
Gene Symbol: CARD14
CARD14
0.700 GeneticVariation disease BEFREE Rare, highly penetrant, gain-of-function, dominantly acting mutations within the human caspase recruitment domain family, member 14 (CARD14) gene lead to the development of PS and psoriatic arthritis (PSA) (a familial p.G117S and de-novo p.E138A alteration). 31323190 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Salidroside inhibits MAPK, NF-κB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation. 31495284 2019
Entrez Id: 79092
Gene Symbol: CARD14
CARD14
0.700 GeneticVariation disease BEFREE Although dominant gain-of-function mutations in CARD14 are associated with psoriasis and related diseases, loss-of-function mutations in the same gene are associated with a severe variant of AD. 30248356 2019
Entrez Id: 79092
Gene Symbol: CARD14
CARD14
0.700 GeneticVariation disease BEFREE Consistently, many psoriasis susceptibility genes encode the TRAF6 signaling players, such as ACT1 (<i>TRAF3IP2</i>), A20 (<i>TNFAIP3</i>), ABIN1 (<i>TNIP1</i>), IL-36Ra (<i>IL36RN</i>), IkappaBzeta (<i>NFKBIZ</i>), and CARD14. 31156649 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Our study suggests that Stat3 activation in keratinocytes may impact on LC activation in situ via IL-1α stimulation, at least in part, and that their presence may be essential for the pathogenesis of psoriasis through producing IL-23. 30514663 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Further, AS2762900-00 showed an inhibitory effect on signal transducer and activator of transcription 3 (STAT3) phosphorylation as a downstream signal of IL-23 receptor activation in whole blood from patients with psoriasis. 30472202 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Genistein suppresses psoriasis-related inflammation through a STAT3-NF-κB-dependent mechanism in keratinocytes. 30743203 2019
Entrez Id: 79092
Gene Symbol: CARD14
CARD14
0.700 GeneticVariation disease BEFREE It is known that particular caspase recruitment domain family member 14 (CARD14) gene mutations are associated with familial PRP and certain forms of psoriasis. 30697821 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 AlteredExpression disease BEFREE Several common TFs that bind the promoters of the DEGs, including the well-known signal transducer and activator of transcription 1 (STAT1), STAT3, and nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) as well as ETS homologous factor (EHF), Fos-like antigen 1 (FOSL1), and Forkhead box C1 (FOXC1), which are rarely studied in psoriasis, were also identified. 30825251 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Silencing the target gene STAT3 in psoriatic KCs with siRNA combined with ultrasonic irradiation and microbubbles would contribute to a significant innovation as a new clinical therapy for psoriasis. 30127220 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 GeneticVariation disease BEFREE Psoriasis: A STAT3-Centric View. 29316631 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 AlteredExpression disease BEFREE It was observed that 'psoriasis 1' downregulated the concentrations of TNF‑α, IFN‑γ, IL‑22, IL‑17C, IL‑1β and IL‑4, and upregulated the concentration of 25HVD3; furthermore, 'psoriasis 1' downregulated the expression levels of NF‑κB, phosphorylated (p)‑NF‑κB, IKK, p‑IKK, STAT3, p‑STAT3, STAT4 and p‑STAT4, and upregulated the expression level of VDR in TNF‑α‑induced HaCaT cells. 30015892 2018
Entrez Id: 79092
Gene Symbol: CARD14
CARD14
0.700 GeneticVariation disease BEFREE Similarly, mutations in the CARD14 gene have been linked to pustular types of psoriasis and familiar cases of pityriasis rubra pilaris; however, there are no reports associating mutations in the CARD14 gene with AGEP. 28776328 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Taken together, our findings indicated that the curative effects of CTS on psoriasis are accomplished mainly through modulating STAT3, which providing evidences to develop CTS as a potential therapeutic agent for patients with psoriasis. 29427477 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 AlteredExpression disease BEFREE STAT3 was overexpressed in the intestinal mucosa of active and non-active IBD, and a similar upregulation was seen in skin biopsies from EN [84.7 vs 22.3, p < 0.001] and PG [60.5 vs 22.3, p = 0.011], but not in psoriasis. 29182760 2018
Entrez Id: 79092
Gene Symbol: CARD14
CARD14
0.700 Biomarker disease GENOMICS_ENGLAND Thus, CARMA2 serves as a key mediator of IL-17A signaling and its constitutive activation in keratinocytes leads to the onset of psoriasis, which indicates an important role of NF-κB activation in keratinocytes in psoriatic initiation. 29980436 2018
Entrez Id: 79092
Gene Symbol: CARD14
CARD14
0.700 Biomarker disease BEFREE Rare autosomal mutations in CARD14 have previously been linked to psoriasis susceptibility in humans, but their pathogenic role had not been shown.Mellett et al. generated mice harboring the patient-derived gain-of-function Card14ΔE138 mutation and showed that hyperactivation of CARD14 alone is sufficient to induce immunopathogenic mechanisms that are responsible for psoriasis, which is driven by the IL-17/IL-23 axis. 30143077 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE The IL-22-STAT3-Bcl-3 pathway may be important in the pathogenesis of psoriasis. 28901004 2018
Entrez Id: 79092
Gene Symbol: CARD14
CARD14
0.700 GeneticVariation disease BEFREE Many subjects with CARD14 mutations display characteristics of both psoriasis and PRP. 29477734 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Using a preclinical model of psoriasis, we show that intradermal injection of APTstat3 tagged with a 9-arginine cell-penetrating peptide (APTstat3-9R) reduced disease progression and modulated psoriasis-related cytokine signaling through inhibition of STAT3 phosphorylation. 29949348 2018
Entrez Id: 79092
Gene Symbol: CARD14
CARD14
0.700 Biomarker disease BEFREE These data indicate that CARD14 is essential and a potential therapeutic target for psoriasis. 29150564 2018
Entrez Id: 79092
Gene Symbol: CARD14
CARD14
0.700 Biomarker disease BEFREE Therefore, hyperactivation of CARD14 alone is sufficient to orchestrate the complex immunopathogenesis that drives T helper type 17-mediated psoriasis skin disease in vivo. 29689250 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.700 Biomarker disease BEFREE Our findings indicate that miR-320b negatively regulates NHEK proliferation by targeting AKT3 to regulate the STAT3 and SAPK/JNK signaling pathways and might participate in the pathogenesis of psoriasis in Chinese Han populations. miR-320b may also be a novel diagnostic marker or therapeutic target for this disease. 30136020 2018
Entrez Id: 79092
Gene Symbol: CARD14
CARD14
0.700 GeneticVariation disease BEFREE Following the identification of CARD14 gain-of function mutations as responsible for the psoriasis susceptibility locus <i>PSORS2</i>, the past years have witnessed a large volume of case reports and association studies describing CARD14 variants as causal or predisposing to a wide range of inflammatory skin disorders. 30386326 2018