| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.060 | AlteredExpression | disease | BEFREE | Furthermore, RV-induced IFN-γ stimulates MMP12 expression particularly in CD11b<sup>+</sup>/CD11c<sup>+</sup> macrophages, which may degrade alveolar walls thus leading to progression of emphysema in these mice. | 30952808 | 2019 | ||||
|
0.060 | Biomarker | disease | BEFREE | WT and DNER deficient mice were exposed to CS or filtered air for 3 day and 2 months to assess IFNγ-expressing macrophages and emphysema development. | 31060902 | 2019 | ||||
|
0.060 | Biomarker | disease | BEFREE | Development of autoimmunity in smokers with emphysema is also strongly linked to the expansion of autoreactive T helper (Th) cells expressing interferon gamma (Th1), and interleukin 17A (Th17). | 31112138 | 2019 | ||||
|
0.060 | Biomarker | disease | BEFREE | Analysis of mRNA transcripts of unstimulated lung CD4+ T cell among all subjects identified two distinct molecular correlates of classical COPD clinical phenotypes: basal IL-10 transcripts correlated independently and inversely with emphysema extent (but not spirometry); by contrast, unstimulated IFN-γ transcripts correlated independently and inversely with reduced spirometry (but not reduced DLCO or emphysema extent). | 24805101 | 2014 | ||||
|
0.060 | AlteredExpression | disease | BEFREE | These results suggested that IFN-γ exhibits anti-angiogenesis effects by regulating the expression of TNF-α-induced AmotL1 via NFκB in emphysema lungs. | 23793505 | 2013 | ||||
|
0.060 | Biomarker | disease | BEFREE | Here we demonstrate that interferon gamma (IFN-gamma), a prominent product of CD8(+) cells, causes emphysema with alveolar enlargement, enhanced lung volumes, enhanced pulmonary compliance, and macrophage- and neutrophil-rich inflammation when inducibly targeted, in a transgenic fashion, to the adult murine lung. | 11104801 | 2000 |