Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease BEFREE The differences in mechanical power, TGF-β1, and CTGF between the 2 groups were compared, and the significance of TGF-β1 and CTGF in the diagnosis of ARDS pulmonary interstitial fibrosis were evaluated. 31335733 2019
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease BEFREE Collectively, these data suggest that 810A may potentially be a CTGF-specific, small-molecule antagonist, providing a new method for prevention and treatment of pulmonary fibrosis. 31786302 2019
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 AlteredExpression disease BEFREE Fibrotic protein connective tissue growth factor (CTGF) expression has been confirmed to play a crucial role in lung fibrosis. 31451010 2019
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 AlteredExpression disease BEFREE An in vivo bleomycin-induced PF study showed that an intraperitoneal injection of CUR (30 mg/kg) reduced expressions of α-SMA, CCN2, Col IV, and vimentin in lung tissues via IHC staining using specific antibodies. 30825198 2019
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease BEFREE In addition, the expression of EMT markers (N-cadherin, vimentin, α-SMA and CTGF) were significantly increased indicating their role in silica induced pulmonary fibrosis. 29964173 2018
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 AlteredExpression disease BEFREE Furthermore, GPS significantly downregulated the expression of TGF-β1 and CTGF in lungs of PF mice. 29278701 2018
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 AlteredExpression disease BEFREE Connective tissue growth factor (CTGF) overexpression underlies the development of pulmonary fibrosis. 29499695 2018
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease BEFREE Several studies indicated that thrombin, a disintegrin and metalloproteinase 17 (ADAM17), and connective tissue growth factor (CTGF) participate in the formation of pulmonary fibrosis. 29902535 2018
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease BEFREE lncRNA PFAL promotes lung fibrosis through CTGF by competitively binding miR-18a. 29683732 2018
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 AlteredExpression disease BEFREE Withaferin A treatment reduced the progression of PF by modulating the EMT related cell markers both <i>in vivo</i> and <i>in vitro.</i> Withaferin A ameliorated the expression of inflammatory cytokines including NF-κB p65, IL-1β and TNF-α, as well as attenuated the expression of pro-fibrotic proteins including CTGF, collagen 1A2, collagen 3A1, and fibronectin. 29623041 2018
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease BEFREE Since IRF5, STAT4, and IRAK1 are important regulatory factors in the control of innate immune responses and CTGF is involved in the synthesis of extracellular matrix, these results suggest a role of the innate immunity and matrix compounds in the pathogenesis of PF in SSc. 28434122 2017
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease BEFREE Effects of CTGF Blockade on Attenuation and Reversal of Radiation-Induced Pulmonary Fibrosis. 28376190 2017
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease BEFREE Chol-HCQ nanocarriers reduce early pulmonary inflammation and inhibit the CTGF/ERK signalling pathway in bleomycin-induced pulmonary fibrosis. 28878315 2017
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease BEFREE Connective tissue growth factor (CTGF) has been proposed as a key determinant in the development of lung fibrosis. 26129822 2016
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease CTD_human Last, the in vivo silencing efficacy of SAMiRNAs was evaluated by targeting amphiregulin and connective tissue growth factor in bleomycin or TGF-β transgenic animal models of pulmonary fibrosis. 26817844 2016
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease BEFREE Several reports have indicated that hypoxia, GLI, and connective tissue growth factor (CTGF) contribute to pulmonary fibrosis in idiopathic pulmonary fibrosis. 27486656 2016
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease BEFREE In the present study, the role of CTGF was examined in a rat model of pulmonary fibrosis induced by PQ poisoning. 25815693 2015
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 AlteredExpression disease BEFREE Collectively, this study implies a significant fibrogenic induction activity of rapamycin by activating AKT and inducing CCN2 expression in vitro and provides the possible mechanisms for the in vivo findings which previously showed no antifibrotic effect of rapamycin on lung fibrosis. 26192087 2015
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease CTD_human In the present study, the role of CTGF was examined in a rat model of pulmonary fibrosis induced by PQ poisoning. 25815693 2015
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease BEFREE Current knowledge confers a crucial role of CCN2 in lung fibrosis. 24276150 2014
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Therapeutic disease RGD Roflumilast, a phosphodiesterase 4 inhibitor, alleviates bleomycin-induced lung injury. 19154443 2009
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease BEFREE Transgenic mice that were carrying luciferase and beta-galactosidase reporter genes driven by the Col1a2 enhancer/promoter and the CTGF promoter, respectively, were injected with bleomycin to induce lung fibrosis (or saline as control), and the extracted pulmonary fibroblasts were incubated with CTGF blocking agents. 19565505 2009
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 AlteredExpression disease BEFREE Decreased CTGF expression may inhibit vascular development or remodeling and limit lung fibrosis during remodeling. 16936247 2007
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease CTD_human In this study we used human lung fibroblasts derived from healthy and IPF lungs to examine Simvastatin effects on CTGF gene and protein expression, analyzed by RT-PCR and ELISA, respectively. 15677772 2005
Entrez Id: 1490
Gene Symbol: CCN2
CCN2
0.700 Biomarker disease CTD_human We also show that geranylgeranylpyrophosphate (GGPP), but not farnesylpyrophosphate, induces CTGF promoter activity following simvastatin inhibition by 55.3 and 31.1% over GGPP-negative cultures in IMR90 and IPF-derived fibroblasts, respectively, implicating small GTPase Rho involvement rather than Ras in these effects. 15298857 2004