| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
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0.360 | AlteredExpression | disease | BEFREE | IGF-1 (insulin-like growth factor 1) expression was increased and induced a fourfold increase of an ERE construct.<b>Conclusions:</b> Our data show <i>1</i>) a critical role for ER and let-7 in lung fibrosis, and <i>2</i>) that IGF may stimulate ER in an E<sub>2</sub>-independent manner. | 31291549 | 2019 | ||||
|
0.360 | Biomarker | disease | BEFREE | Our results show that miR-130b-3p was downregulated in IPF lungs. miR-130b-3p downregulation contributed to the activation of fibroblasts and the dysregulated epithelial-mesenchymal crosstalk by promoting IGF-1 secretion from lung epithelium, suggesting a key regulatory role for this miRNA in preventing lung fibrosis. | 26953888 | 2016 | ||||
|
0.360 | Biomarker | disease | BEFREE | Insulin-like growth factor-I (IGF-I) is significantly elevated in patients with pulmonary fibrosis and fibroproliferative acute respiratory distress syndrome. | 22923639 | 2012 | ||||
|
0.360 | Biomarker | disease | BEFREE | Insulin-like growth factor I (IGF-I) has been shown to stimulate lung mesenchymal cell proliferation and extracellular matrix synthesis in vitro and is significantly elevated in patients with PF. | 20081067 | 2010 | ||||
|
0.360 | AlteredExpression | disease | BEFREE | Patients with increased IGF-1 levels had more severe skin involvement and pulmonary fibrosis. | 19004037 | 2008 | ||||
|
0.360 | AlteredExpression | disease | LHGDN | Patients with increased IGF-1 levels had more severe skin involvement and pulmonary fibrosis. | 19004037 | 2008 | ||||
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0.360 | AlteredExpression | disease | BEFREE | These findings suggest that increased expression of human IGF-IA in alveolar air spaces does not affect the development of pulmonary fibrosis but promotes premalignant changes in the alveolar epithelium. | 15618451 | 2005 | ||||
|
0.360 | Biomarker | disease | CTD_human | We further used immunohistochemistry (IHC) to examine the relative role of platelet-derived growth factor-B (PDGF-B), insulin-like growth factor I (IGF-I), transforming growth factor-beta1 (TGF-beta1) and cyclooxygenase-2 (COX-2) in the pathogenesis of BCNU-related pulmonary fibrosis. | 15286697 | 2004 |