| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.380 | Biomarker | disease | BEFREE | Further, the long-term nintedanib therapy attenuated fibrocyte accumulation, collagen deposition, and lung function decline during TGFα-induced pulmonary fibrosis. | 31156440 | 2019 | ||||
|
0.380 | Biomarker | disease | BEFREE | We conclude that self-gating UTE MRI could be used to longitudinally monitor lung fibrosis in the TGF-α transgenic mouse model. | 30730810 | 2019 | ||||
|
0.380 | Biomarker | disease | BEFREE | Immunohistochemical analysis of αvβ6 protein expression and bronchoalveolar analysis of TGF-β pathway signaling indicates activation of the αvβ6/TGF-β pathway only at later time points after lung fibrosis was already established in the TGF-α model. | 24508732 | 2014 | ||||
|
0.380 | Biomarker | disease | BEFREE | To determine the role of the MEK pathway in the induction of TGF-α-induced lung fibrosis, TGF-α was overexpressed for 4 weeks while mice were simultaneously treated with the specific MEK inhibitor, ARRY-142886 (ARRY). | 22021337 | 2012 | ||||
|
0.380 | Biomarker | disease | BEFREE | Finally, we will present data demonstrating a minimal contribution of epithelial-mesenchymal transition in the development of fibrotic lesions in the transforming growth factor-alpha transgenic model of lung fibrosis. | 20676040 | 2010 | ||||
|
0.380 | Biomarker | disease | BEFREE | Induction in the lung of TGF-alpha caused progressive pulmonary fibrosis over a 7-week period. | 19244201 | 2009 | ||||
|
0.380 | Biomarker | disease | CTD_human | Induction in the lung of TGF-alpha caused progressive pulmonary fibrosis over an 8-wk period. | 18424623 | 2008 | ||||
|
0.380 | Biomarker | disease | BEFREE | Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis. | 17496152 | 2007 | ||||
|
0.380 | AlteredExpression | disease | BEFREE | Transgenic mice expressing transforming growth factor alpha (TGF-alpha) in type II cells under control of the lung-specific surfactant protein-C (SP-C) promoter develop pulmonary fibrosis and marked airspace hypoplasia. | 8879184 | 1996 |