|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results have shown that HLA-DRB1*01 and HLA-DRB1*11 (<i>P</i> = 0.002, odds ratio [OR] = 7.579, confidence interval [CI] = 1.934-29.697 and <i>P</i> = 0.039, OR = 3.333, CI = 1.030-10.788), respectively, are the most frequent alleles associated with HSP in Iranian children population.
|
29937904 |
2018 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim was to investigate the association of HLA-DRB1 (HLA class II antigen) with HSP.
|
27184863 |
2016 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since a former study described an association between HLA-DRB1*01:03 and HSP susceptibility, we also evaluated the implication of HLA-B*41:02 independently of HLA-DRB1*01:03.
|
25889603 |
2015 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The overall odds ratios (ORs) for the three loci were significant for HSP: HLA-DRB1 01 (OR = 1.805, 95 % CI 1.259-2.588, p = 0.0012); HLA-DRB1 07 (OR = 0.671, 95 % CI 0.469-0.961, p = 0.058); HLA-DRB1 11 (OR = 2.001, 95 % CI 1.50-2.67, p = 0.027).
|
23325094 |
2013 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, HLA-DRB1*11 positivity was increased and HLA-DRB1 14 positivity reduced in HSP patients with joint manifestations (OR = 2.68, 95% CI = 1.09-6.66, p = 0.029; OR = 9.34, 95% CI = 3.38-25.64, p = 0.000, respectively).
|
18412308 |
2008 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggested that CTLA-4 +49 A/G polymorphism does not contribute to susceptibility to HSP; however, the presence of CTLA-4 AG genotype and HLA-DRB1*13 could be a risk factor for developing nephrotic-range proteinuria in these patients.
|
18449568 |
2008 |
|
HLA-DRB1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Human leukocyte antigen (HLA) typing in the patient disclosed the DRB1*11 allele, which has been reported to be associated with HSP, but the brother proved negative, suggesting that this allele was irrelevant to the HSP pathogenesis.
|
16874703 |
2006 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
When HLA-DRB1 genotypes of patients with CLA and HSP were compared a significant increase of HLA-DRB1*15/16 and especially of HLA-DRB1*07 was observed in the patients fulfilling definitions for CLA compared to those with HSP.
|
12022354 |
2002 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients with HSP had a significantly higher frequency of the HLA-DRB1*01 phenotype compared to matched controls.
|
11409118 |
2001 |
|
HLA-DRB1
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that susceptibility to HS also has a genetic origin: on one hand, the presence of DRB1*01 or DRB1*11 makes disease onset easier; on the other hand, DRB1*07 could induce some resistance to the disease.
|
9442800 |
1997 |