To address BBB-targeting and -crossing issues, PEGylated Nano-BA<sub>12K</sub> was formulated with a specific brain-targeting peptide (rabies virus glycopeptide-29, RVG<sub>29</sub>) and a P-glycoprotein inhibitor (Pluronic<sup>®</sup> P85 unimers) to construct a mixed micellar system (RVG<sub>29</sub>-Nano-BA<sub>P85</sub>).