EGPA patients with relapse had more frequent baseline MPO-ANCA and kidney involvement,including proteinuria over 1 g/day and renal insufficiency and higher FFS at diagnosis than those without.
In addition, we discussed the role of modified lipoprotein particles under the influence of prooxidant MPO intermediates in the development of endothelial changes and cardiovascular complications in renal failure.
There was no difference in survival to renal failure or death in patients with the different MPO alleles (chi(2) = 0.904, P = 0.6362) or in presenting serum creatinine concentration based on MPO genotype (chi(2) = 0.389, P = 0.8232).
The relationship observed between polymorphisms of the TNF and MPO genes and chronic renal failure may depend on the pathophysiological changes in different diseases underlying renal failure.