| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Surfactant based on a recombinant surfactant protein C analogue (rSP-C33Leu) is easy to produce and in this study we compared its effects on lung function and inflammation with a commercial surfactant preparation in an adult rabbit model of ARDS. | 31694668 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | This study focuses on a new mechanism of SPC as an anti-inflammatory molecule using SPC-TK/SPC-KO (surfactant protein C-thymidine kinase/surfactant protein C knockout) mice, which represent a novel sterile injury model that mimics clinical acute respiratory distress syndrome (ARDS). | 29345196 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | CHF5633 is a new generation synthetic surfactant containing both SP-B and SP-C analogues developed for the treatment of respiratory distress syndrome. | 27973472 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome. | 28465315 | 2017 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Expression of SP-C and Ki67 in lungs of preterm infants dying from respiratory distress syndrome. | 23027351 | 2012 | ||||
|
0.080 | Biomarker | disease | BEFREE | The BRICHOS domain was initially defined from sequence alignments of the Bri protein associated with familial dementia, chondromodulin associated with chondrosarcoma and surfactant protein C precursor (proSP-C) associated with respiratory distress syndrome and interstitial lung disease (ILD). | 21668643 | 2011 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Our data provide evidence that ABCA3 mutations are associated not only with a deficiency of ABCA3 but also with an abnormal processing and routing of SP-B and SP-C, leading to severe alterations of surfactant homeostasis and respiratory distress syndrome. | 16728712 | 2006 | ||||
|
0.080 | Biomarker | disease | BEFREE | Surfactant replacement therapy with bovine and porcine lung surfactant extracts, which contain only polar lipids and SP-B and SP-C, has revolutionized the clinical management of premature infants with respiratory distress syndrome. | 11001826 | 2000 |