| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | group | BEFREE | Transcription and translation of cyclin-dependent kinase inhibitor 1 (p21<sup>Cip1</sup>) and SAM domain and HD domain-containing protein 1 (SAMHD1) were analyzed by TaqMan PCR and Western blot experiments. siRNA experiment was applied to study the role of p53 downstream gene p21<sup>Cip1</sup> in the restriction of retrovirus infection. | 28793904 | 2017 | ||||
|
0.070 | Biomarker | group | BEFREE | SAMHD1 blocks retroviral infection at the level of reverse transcription in myeloid cells and resting CD4+ T cells and is counteracted by the accessory protein Vpx, which is encoded by human immunodeficiency virus 2 (HIV-2) and several simian immunodeficiency virus (SIV) strains. | 26957197 | 2016 | ||||
|
0.070 | Biomarker | group | BEFREE | Our findings show that SAMHD1 in the mouse blocks retroviral infection at the level of reverse transcription and is regulated through cell cycle-dependent phosphorylation. | 26667483 | 2015 | ||||
|
0.070 | AlteredExpression | group | BEFREE | Host restriction factors such as SAMHD1 and Trex1 play important roles in regulating innate immune sensing, and have led to the idea that innate immune defense and host restriction actually converge at different levels to determine the outcome of retroviral infection. | 25240798 | 2014 | ||||
|
0.070 | Biomarker | group | BEFREE | Collectively, these findings indicate that phosphorylation modulates the ability of SAMHD1 to block retroviral infection without affecting its ability to decrease cellular dNTP levels. | 23601106 | 2013 | ||||
|
0.070 | Biomarker | group | BEFREE | Both studies suggest that SAMHD1 is important for regulating the intracellular dNTP pool and the intrinsic immunity against retroviral infection, despite different outcomes of HIV-1 vector transduction in these mouse models. | 24257155 | 2013 | ||||
|
0.070 | Biomarker | group | BEFREE | SAMHD1 host restriction factor: a link with innate immune sensing of retrovirus infection. | 24161438 | 2013 |