Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.050 Biomarker group BEFREE Unexpectedly, knockout of PQBP1 in THP-1 cells causes significantly increased type I IFN production in response to transfected cytosolic nucleic acids or DNA damage, unlike what is seen in response to retroviral infection. 29807326 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.050 Biomarker group BEFREE Recent studies addressed the important question if other IFNα subtypes would be more potent against retroviral infections in in vitro and in vivo experiments. 29475588 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.050 Biomarker group BEFREE Surprisingly, we also identified an impaired suppressive capability of regulatory T cells in the presence of IFNα, which implicates an important role for vaccine-induced IFNα in the regulation of the T cell response during chronic retroviral infection. 29740425 2018
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.050 Biomarker group BEFREE The APOBEC3 (A3) family of proteins are DNA cytidine deaminases that act as sentinels in the innate immune response against retroviral infections and are responsive to IFN. 28232385 2017
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.050 Biomarker group BEFREE These findings reveal that IFN-α inhibits acute Friend retrovirus infection primarily through the antiviral effector Apobec3 in vivo, demonstrate that transcriptional induction levels did not predict the mechanism of IFN-α-mediated control, and highlight the potential of the human APOBEC3 proteins as therapeutic targets against pathogenic retrovirus infections. 23315078 2013