Our findings suggest that the mouse APOBEC3 cytidine deaminase activity is not required for retrovirus restriction.<b>IMPORTANCE</b> APOBEC3 proteins are important host cellular restriction factors essential for restricting retrovirus infection by causing mutations in the virus genome and by blocking reverse transcription.
Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is a host cytidine deaminase that is packaged into virions and confers resistance to retroviral infection.