Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 13
Gene Symbol: AADAC
AADAC
0.010 AlteredExpression disease BEFREE The TE.32.7-DAC-resistant cell line exhibited cross-resistance to vincristine and doxorubicin and showed mdr1/P-glycoprotein over-expression, suggesting that this mechanism was involved in the reduction in intracellular drug concentration and may be responsible for the failure of treatment of RMS with classical cycles of cytotoxics. 9455797 1998
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.050 Biomarker disease BEFREE Our results indicated that positive RMS samples to mdr1 show higher HLA class I expression than those which were negative to mdr1 PCR, what indicates a significant correlation between the expression of both molecules. 16652192 2006
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.050 AlteredExpression disease BEFREE The TE.32.7-DAC-resistant cell line exhibited cross-resistance to vincristine and doxorubicin and showed mdr1/P-glycoprotein over-expression, suggesting that this mechanism was involved in the reduction in intracellular drug concentration and may be responsible for the failure of treatment of RMS with classical cycles of cytotoxics. 9455797 1998
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.050 AlteredExpression disease BEFREE Twenty-three rhabdomyosarcoma samples were analyzed for the expression of MDR-1 and MRP genes using a semi-quantitative competitive RT-PCR assay. 14654923 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.050 GeneticVariation disease BEFREE The statistical analysis of results showed that the cases of tetraploid and/or multiploid RMS, overexpressing p53 (W&M and mutated) and MDR-1, were characterized by an overall worse prognosis. 15015604 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.050 AlteredExpression disease BEFREE The pattern of resistance and the level of P-glycoprotein expression were similar to those found in the resistant RMS TE.32.7.DAC cell line obtained in vitro. 10470293 1999
Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
0.010 Biomarker disease BEFREE Interestingly, MDR3 was significantly associated with the presence of PAX3/PAX7-FKHR transcripts in RMS (p<0.05). 22504834 2012
Entrez Id: 4363
Gene Symbol: ABCC1
ABCC1
0.020 AlteredExpression disease BEFREE These findings suggest that MRP expression could be a prognostic factor in patients with rhabdomyosarcoma. 14654923 2004
Entrez Id: 4363
Gene Symbol: ABCC1
ABCC1
0.020 Biomarker disease BEFREE We investigated the expression of 3 MDR proteins, i.e., permeability glycoprotein 1 (P-gp), multidrug resistance-associated protein 1 (MRP1) and multidrug resistance 3 (MDR3), in 43 STS specimens from newly-diagnosed paediatric patients, 31 with rhabdomyosarcoma (RMS) and 12 with non-RMS STS. 22504834 2012
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.020 AlteredExpression disease BEFREE Our study is focused on immunohistochemical analysis of nestin, CD133 and ABCG2 expression in rhabdomyosarcoma, Ewing sarcoma and osteosarcoma. 27314299 2016
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.020 GeneticVariation disease BEFREE These results suggest that at least 2 different mechanisms--inhibition of ABCG2 and/or PDGFRbeta--are involved in the synergistic interaction between imatinib and TPT, and support the use of this combination for the treatment of high-risk RMS patients. 17131346 2007
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
0.030 Biomarker disease BEFREE Regulation of expression of stromal-derived factor-1 receptors: CXCR4 and CXCR7 in human rhabdomyosarcomas. 20068066 2010
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
0.030 AlteredExpression disease BEFREE The expression of CXCR7 differed between rhabdomyosarcoma subtypes. 20529825 2010
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
0.030 Biomarker disease BEFREE Expression of the Chemokine Receptors CXCR3, CXCR4, CXCR7 and Their Ligands in Rhabdomyosarcoma. 26037167 2015
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.040 Biomarker disease BEFREE The use of Northern blots for alpha-CARD actin as an adjunct to conventional techniques may be helpful for the precise identification of primary RMSs compared to other soft tissue neoplasms. 8160781 1994
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.040 Biomarker disease BEFREE Taken together with the results of recent reports indicating that the cardiac alpha-actin type is a marker of embryonic and fetal skeletal muscle, our findings indicate that rhabdomyosarcomas express the embryonic sarcomeric actin isoform. 3443230 1987
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.040 Biomarker disease BEFREE The present study indicates that both muscle-specific actin and desmin can be expressed in tumors lacking ultrastructural evidence of a rhabdomyoblastic differentiation and that the combined use of monoclonal antibodies to desmin and muscle-specific actin is of value when it comes to recognizing rhabdomyosarcomas within the group of undifferentiated small and dark cell malignancies of soft tissue tumors. 2282206 1990
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.040 Biomarker disease BEFREE In addition, MAbs to the cytoplasmic protein desmin, myoglobin, muscle actin (alpha and gamma) and alpha-sarcomeric actin reacted with these cell lines, SCMC-RM2 and SCMC-RM2-1 being thus identified as rhabdomyosarcoma. 2323848 1990
Entrez Id: 86
Gene Symbol: ACTL6A
ACTL6A
0.010 Biomarker disease BEFREE These results indicate that failure to downregulate the BAF53a subunit may contribute to the pathogenesis of RMS, and suggest that BAF53a may represent a novel therapeutic target for this tumor. 23728344 2014
Entrez Id: 94
Gene Symbol: ACVRL1
ACVRL1
0.010 AlteredExpression disease BEFREE This study demonstrates that in addition to IMT, abnormalities of ALK1 and p80 expression with a variety of structural chromosomal changes are found in several sarcomas, especially rhabdomyosarcoma and malignant peripheral nerve sheath tumor. 12218210 2002
Entrez Id: 177
Gene Symbol: AGER
AGER
0.010 AlteredExpression disease BEFREE These data suggest that deregulation of RAGE expression in myoblasts might concur in rhabdomyosarcomagenesis and that increasing RAGE expression in rhabdomyosarcoma cells might reduce their tumor potential. 17640970 2007
Entrez Id: 177
Gene Symbol: AGER
AGER
0.010 AlteredExpression disease LHGDN These data suggest that deregulation of RAGE expression in myoblasts might concur in rhabdomyosarcomagenesis and that increasing RAGE expression in rhabdomyosarcoma cells might reduce their tumor potential. 17640970 2007
Entrez Id: 10598
Gene Symbol: AHSA1
AHSA1
0.020 AlteredExpression disease BEFREE Our study showed that RMS cells respond to sub-physiological levels of T stimulation, finally promoting AR-dependent genomic and non-genomic effects, such as the transcriptional regulation of several oncogenes, the phosphorylation-mediated post-transductional modifications of AR and the activation of ERK, p38 and AKT signal transduction pathway mediators that, by physically complexing or not with AR, participate in regulating its transcriptional activity and the expression of T-targeted genes. 29790086 2019
Entrez Id: 10598
Gene Symbol: AHSA1
AHSA1
0.020 Biomarker disease BEFREE PKCalpha-mediated ERK, JNK and p38 activation regulates the myogenic program in human rhabdomyosarcoma cells. 12186945 2002
Entrez Id: 7965
Gene Symbol: AIMP2
AIMP2
0.020 AlteredExpression disease BEFREE Our study showed that RMS cells respond to sub-physiological levels of T stimulation, finally promoting AR-dependent genomic and non-genomic effects, such as the transcriptional regulation of several oncogenes, the phosphorylation-mediated post-transductional modifications of AR and the activation of ERK, p38 and AKT signal transduction pathway mediators that, by physically complexing or not with AR, participate in regulating its transcriptional activity and the expression of T-targeted genes. 29790086 2019