| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.470 | GeneticVariation | disease | BEFREE | The V550E/L and N535D/K mutations of FGFR4 in RMS can lead to strong drug resistance to almost all of the type-I inhibitors. | 31128178 | 2019 | ||||
|
0.470 | GeneticVariation | disease | BEFREE | This study tested FGFR4-activating mutations and overexpression for the ability to generate RMS in mice. | 29487419 | 2018 | ||||
|
0.470 | GeneticVariation | disease | BEFREE | Missense mutations of FGFR2 are found in endometrial uterine cancer and melanoma, and similar FGFR3 mutations in invasive bladder tumors, and FGFR4 mutations in rhabdomyosarcoma. | 23696246 | 2014 | ||||
|
0.470 | GeneticVariation | disease | CLINVAR | Targeting wild-type and mutationally activated FGFR4 in rhabdomyosarcoma with the inhibitor ponatinib (AP24534). | 24124571 | 2013 | ||||
|
0.470 | Biomarker | disease | BEFREE | Therefore, FGFR4 is a tractable therapeutic target for patients with RMS. | 24124571 | 2013 | ||||
|
0.470 | AlteredExpression | disease | BEFREE | FGFR4 is expressed in both RMS subtypes, but protein expression is higher in aRMS. | 22648271 | 2012 | ||||
|
0.470 | AlteredExpression | disease | BEFREE | Finally, murine RMS cell lines expressing the K535 and E550 FGFR4 mutants were substantially more susceptible to apoptosis in the presence of a pharmacologic FGFR inhibitor than the control cell lines expressing the empty vector or wild-type FGFR4. | 19809159 | 2009 | ||||
|
0.470 | GeneticVariation | disease | CLINVAR | Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. | 19809159 | 2009 | ||||
|
0.470 | AlteredExpression | disease | BEFREE | Using Northern blotting, reverse transcription-polymerase chain reaction, and Western blotting, we classified four human rhabdomyosarcoma-derived cell lines based on their relative expression of FGFR4. | 15475466 | 2004 | ||||
|
0.470 | CausalMutation | disease | CGI |