| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | GeneticVariation | disease | BEFREE | Planned Phase 2 trials include targeted agents for VEGF/PDGF, mTOR, and IGF-1R for children with RMS and VEGF for children with non-RMS STS (NRSTS). | 23255356 | 2013 | ||||
|
0.090 | Biomarker | disease | BEFREE | Additionally, several studies have shown a significant involvement of IGF pathway in the pathogenesis of RMS. | 23079386 | 2012 | ||||
|
0.090 | Biomarker | disease | BEFREE | The PAX3-FOX01 gene fusion and the IGF-1R-signaling and mTOR-signaling pathways are implicated in rhabdomyosarcoma biology, and hence are promising therapeutic targets for this tumor. | 18391632 | 2008 | ||||
|
0.090 | Biomarker | disease | BEFREE | These results suggest involvement of the PA/plasmin system in IGF-induced migration and indicate important roles these systems may have in RMS metastasis. | 12942549 | 2003 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Known genes in its proximity include myogenic regulators Myf5 and Myf6, growth factor Igf1, and another potential differentially expressed gene (ATP2B1) in RMS isolated by RDA. | 12082533 | 2002 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Interestingly, IGF1 does not enhance myogenin expression in Rhabdomyosarcoma-derived RD cells. | 10973962 | 2000 | ||||
|
0.090 | Biomarker | disease | BEFREE | Our data suggest that the IGF/IGF-I-R signaling pathway may be inhibited by expressing a mutated IGF-I-KR and that such a mutant gene could be utilized in developing novel therapeutic strategies to suppress RMS growth.1998. | 9537584 | 1998 | ||||
|
0.090 | Biomarker | disease | BEFREE | We conclude that IN157 cells express high levels of bioactive 10 kDa IGF-II and 7.5 kDa IGF-II that may stimulate the proliferation of rhabdomyosarcomas by interaction with IGF-I receptors on the cells. | 7686519 | 1993 | ||||
|
0.090 | Biomarker | disease | BEFREE | The present study demonstrates by molecular hybridization and immunoreactivity that the human counterpart of rat BP-3A is a 34 kDa IGF binding protein that is present in human cerebrospinal fluid and is synthesized and secreted by the A673 human rhabdomyosarcoma cell line. | 2476983 | 1989 |