Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 Biomarker disease BEFREE The histological diagnosis was alveolar (RMA) (n = 38, 23/25 examined patients PAX7/3:FOXO1-positive), embryonal (RME) (n = 100), botryoid (n = 10), anaplastic (n = 1), and spindle-cell RMS (n = 6). 30762282 2019
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 Biomarker disease BEFREE Only the ten biopsies involved by Ewing sarcoma and four biopsies with rhabdomyosarcoma showed strong nuclear PAX7 staining. 30014288 2018
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 AlteredExpression disease BEFREE Recent tissue microarray studies suggested that PAX7 is a novel marker, because it was expressed consistently in Ewing sarcoma, in addition to rhabdomyosarcoma and synovial sarcoma. 29920735 2018
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 AlteredExpression disease BEFREE We previously demonstrated PAX7 expression as a marker of skeletal muscle differentiation in rhabdomyosarcoma. 28643791 2017
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 Biomarker disease BEFREE Specifically, we determined that PAX7 downregulation is necessary for miR-206-induced cell cycle exit and myogenic differentiation in FN-RMS but not in FP-RMS. 27277678 2016
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 Biomarker disease BEFREE For treatment stratification, RMS is further subclassified as fusion-positive (FP-RMS) or fusion-negative (FN-RMS), depending on whether a gene fusion involving PAX3 or PAX7 is present or not. 26482321 2016
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 GeneticVariation disease BEFREE Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma and includes a PAX3- or PAX7-FOXO1 fusion-positive subtype. 25810375 2015
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 AlteredExpression disease BEFREE In our studies we employed eight rhabdomyosarcoma (RMS) cell lines (three alveolar-type RMS cell lines and five embrional-type RMS cell lines), and mRNA samples obtained from positive, PAX7-FOXO1-positive, and fusion-negative RMS patient samples. 26412593 2015
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 GeneticVariation disease BEFREE One major subgroup of RMS tumors (so-called "fusion-positive" tumors) carries exclusive chromosomal translocations that join the DNA-binding domain of the PAX3 or PAX7 gene to the transactivation domain of the FOXO1 (previously known as FKHR) gene. 25368019 2014
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 GeneticVariation disease BEFREE Rhabdomyosarcoma (RMS) is divided into two major histological subtypes: alveolar (ARMS) and embryonal (ERMS), with most ARMS expressing one of two oncogenic genes fusing PAX3 or PAX7 with FOXO1 (P3F and P7F, respectively). 23526739 2013
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 Biomarker disease BEFREE Interestingly, MDR3 was significantly associated with the presence of PAX3/PAX7-FKHR transcripts in RMS (p<0.05). 22504834 2012
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 Biomarker disease BEFREE Convenience cohorts have been used to investigate the prognostic significance of chromosomal translocations between the PAX3 or PAX7 and the FOXO1 genes in rhabdomyosarcoma, the most common pediatric sarcoma. 22564868 2012
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 AlteredExpression disease LHGDN PAX--FKHR fusion genes and AChR-gamma in Chinese patients with rhabdomyosarcoma: diagnosis using formalin-fixed archival tissues. 18988640 2009
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 Biomarker disease BEFREE Therefore, RMS-II represents a promising peptide for the development of RMS-specific targeting approaches. 19123480 2009
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 Biomarker disease BEFREE Using immunohistochemistry, we characterized two markers, HMGA2 and TFAP2ss, which facilitate the differential diagnoses of ERMS and P-F RMS, respectively, using clinical material. 19147825 2009
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 AlteredExpression disease BEFREE The aim of this study is to identify immunohistochemical markers of potential prognostic significance in pediatric RMS and to correlate their expression with PAX-3/FKHR and PAX-7/FKHR fusion status. 18708938 2008
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 Biomarker disease BEFREE A less frequent variant translocation t(1;13) involves another PAX family gene, /PAX7/, located in chromosome 1 and /FOXO1/ and is present in 10-15% of cases of the alveolar subtype in RMS. 17652054 2007
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 GeneticVariation disease BEFREE Real-time RT-PCR assays specific for Ewing's sarcoma (EWS-FLI1, EWS-ERG, EWS-ETV1, EWS-ETV4, and EWS-FEV), synovial sarcoma (SYT-SSX1 and SYT-SSX2), and rhabdomyosarcoma (PAX3-FKHR and PAX7-FKHR) were tested across the samples. 17334332 2007
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 GeneticVariation disease BEFREE The most common types of rhabdomyosarcoma (RMS) are alveolar RMS (ARMS), which are characterized by the specific translocation t(2;13)(q35;q14) or its rarer variant, t(1;13)(p36;q14), producing the fusion genes PAX3-FKHR and PAX7-FKHR, respectively, and embryonal RMS (ERMS), which is characterized by multiple numeric chromosome changes. 16337856 2005
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 AlteredExpression disease LHGDN In conclusion, these studies reveal that PAX3, PAX7 and their fusions with FKHR are each expressed in RMS tumors as a consistent mixture of functionally distinct isoforms. 15688409 2005
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 AlteredExpression disease BEFREE In conclusion, these studies reveal that PAX3, PAX7 and their fusions with FKHR are each expressed in RMS tumors as a consistent mixture of functionally distinct isoforms. 15688409 2005
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 Biomarker disease BEFREE FOXO1 gene is fused to PAX3 or PAX7 genes in rhabdomyosarcoma. 15492844 2004
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 AlteredExpression disease BEFREE This is corroborated by the detection of MET (c-met) expression, a marker for the myogenic satellite cell lineage, in all RMS samples expressing wild-type PAX7. 12865925 2003
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 AlteredExpression disease BEFREE Moreover, Fos is able to repress Pax7 expression in rhabdomyosarcoma cell lines and primary myoblasts, suggesting a molecular link to genetic alterations involved in human rhabdomyosarcomas. 14706339 2003
Entrez Id: 5081
Gene Symbol: PAX7
PAX7
0.100 Biomarker disease BEFREE We determined PAX3-FKHR or PAX7-FKHR fusion status in 171 childhood rhabdomyosarcoma (RMS) patients entered onto the Intergroup Rhabdomyosarcoma Study IV, including 78 ARMS patients, using established reverse transcriptase polymerase chain reaction assays. 12039929 2002