| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | disease | BEFREE | HLA-DRB1 alleles are major determinants of genetic predisposition to rheumatic diseases. | 28899403 | 2017 | ||||
|
0.070 | Biomarker | disease | BEFREE | Novel single nucleotide polymorphism fine-mapping data obtained for the HLA locus have indicated the strongest association with amino acid positions 11 and 13 of HLA-DRB1 molecule for several rheumatic diseases. | 25760279 | 2015 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Thirty percent of RA patients were carrying at least one copy of the HLA-DRB1 shared epitope (SE) compared to 10% and 14% of patients with other inflammatory rheumatic diseases and healthy individuals, respectively. | 20196860 | 2010 | ||||
|
0.070 | GeneticVariation | disease | LHGDN | HLA-DRB1* alleles and temporomandibular joint erosion in patients with various rheumatic diseases. | 15124939 | 2004 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | HLA-DRB1* alleles and temporomandibular joint erosion in patients with various rheumatic diseases. | 15124939 | 2004 | ||||
|
0.070 | Biomarker | disease | BEFREE | On the other hand, only a few patients with the same DRB1 allele developed rheumatic diseases during their life, so other factors besides DRB1 gene might also be involved in the pathogenesis of rheumatic diseases. | 10374416 | 1998 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | In both patients, HLA typing revealed 3 alleles typically associated with rheumatic diseases: HLA-DRB1*0405 and HLA-DQB1*0302 (associated with RA), and HLA-DRB4*01 (associated with mixed connective tissue disease and autoimmune reactions in patients with silicone breast implants. | 9292814 | 1997 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Families were recruited from the Arthritis and Rheumatism Council's National Repository of RA families and HLA-DRB1 alleles were examined in these individuals and their first degree relatives using DNA typing methods. | 7763111 | 1995 |