|
HLA-DRB3
|
0.100 |
Biomarker
|
disease |
BEFREE |
No increase in sarcoidosis was seen with either Glu69 or beryllium exposure (none, <10, ≥10 years) as main effects: longer duration in possible beryllium jobs was related to COPD.
|
25305207 |
2015 |
|
HLA-DRB3
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Initially, we studied the association of sarcoidosis with DQB1, and in the present study, we evaluated all amino acid variants of the HLA-DPB1, -DQB1, -DRB1, -DRB3, -DRB4 and -DRB5 genes to identify possible polymorphisms associated with the disease.
|
17559577 |
2007 |
|
HLA-DRB3
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition to being susceptibility markers, HLA class II alleles may be markers for different phenotypes of sarcoidosis (DRB1*0401 for eye in blacks and whites, DRB3 for bone marrow in blacks, and DPB1*0101 for hypercalcemia in whites).
|
14508706 |
2003 |
|
HLA-DRB3
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-DRB3*0101 as well as DRB1*0301 positive sarcoidosis patients may have the capacity to present specific sarcoidosis associated antigens in such a way that AV2S3+ CD4+ T cells are stimulated preferentially, generating lung restricted AV2S3+ T cell expansions.
|
11923555 |
2002 |
|
HLA-DRB3
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conversely, a lack of DRB1*11 and/or DRB1*12 but not DRB3*0201/2 favored the clinical course of sarcoidosis.
|
11169267 |
2001 |
|
HLA-DRB3
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In previous reports of studies of Scandinavian sarcoidosis patients, we have described a strong association between lung-restricted expansions of T cells expressing T-cell receptor (TCR) AV2S3 and the human leukocyte antigen (HLA)-DRB1*0301 (DR17) and -DRB3*0101 alleles, suggesting the presence of a specific antigen in sarcoidosis.
|
10712327 |
2000 |
|
HLA-DRB3
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our finding of a high frequency of DRB1*08 (which lacks the DRB3 gene encoding the DR52 antigen) in patients living in both eastern Japan and in Hokkaido, confirms that it is the HLA-DRB1 locus, rather than that of the HLA-DRB3, -DQA1, or -DQB1, which determines the susceptibility to sarcoidosis.
|
9130059 |
1996 |
|
HLA-DRB3
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The significantly increased frequency of the DR8 (DRB1*08) haplotype, which lacks the DRB3 gene encoding DR52 antigen, suggested that the DR5 (DRB1*11), DR6 (DRB1*14) and DR8 (DRB1*08) of the DRB1 alleles may determine the susceptibility to sarcoidosis among the Japanese.
|
8739505 |
1996 |
|
HLA-DRB3
|
0.100 |
Biomarker
|
disease |
BEFREE |
The association of DRB3*0101 with sarcoidosis is attributable to linkage disequilibrium with DR5- and DR6-associated alleles.
|
7742275 |
1995 |
|
HLA-DRB3
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the HLA-alleles responsible for the susceptibility to sarcoidosis are located at the HLA-DRB1 locus rather than the HLA-DRB3, -DQA1 and -DQB1 loci.
|
8085259 |
1994 |